| Autor: |
Panagiotidis E; Nuclear Medicine-PET/CT Department 'Theageneio' Cancer Center, Thessaloniki, Greece. andreousotiria@yahoo.gr., Andreou S, Vatalis A, Paschali A, Kalathas T, Pipintakou A, Zoglopitou L, Makridou A, Chatzipavlidiou V |
| Jazyk: |
angličtina |
| Zdroj: |
Hellenic journal of nuclear medicine [Hell J Nucl Med] 2024 Sep-Dec; Vol. 27 (3), pp. 236-242. |
| DOI: |
10.1967/s002449912764 |
| Abstrakt: |
Gallium-68-DOTA-D-phe1-try3-octreotide ( 68 Ga-DOTATOC) positron emission tomography/computed tomography (PET/CT) is a crucial diagnostic tool for neuroendocrine tumors (NET). Its accuracy is influenced by radiochemical purity and patient preparation. We present two cases where unexpected radiotracer uptake in 68 Ga-DOTATOC PET/CT imaging was observed. One case involved high vascular activity and reduced tumor-to-background contrast, attributed to radiochemical impurities. The other case demonstrated blocked somatostatin receptors due to inadequate patient preparation. Both cases highlight the importance of strict radiolabeling protocols and quality control measures, such as thin-layer chromatography (TLC), to ensure accurate 68 Ga-DOTATOC PET/CT results. Additionally, proper patient preparation, including discontinuing somatostatin analogues as recommended, is essential for optimizing diagnostic accuracy. By addressing these factors, healthcare providers can improve the effectiveness of 68 Ga-DOTATOC PET/CT in diagnosing and managing NET. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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