Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches.

Autor: Csulak E; Department of Surgery, Somogy County Teaching Hospital, Kaposvár, 7400, Hungary., Csivincsik Á; Department of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, Kaposvár Campus, Kaposvár, 7400, Hungary., Sréter T; Laboratory Department of Bacteriology, Mycology and Parasitology, National Center for Public Health and Pharmacy, Budapest, 1097, Hungary., Solymosi N; Centre for Bioinformatics, University of Veterinary Medicine, Budapest, 1078, Hungary., Danka J; Laboratory Department of Bacteriology, Mycology and Parasitology, National Center for Public Health and Pharmacy, Budapest, 1097, Hungary., Káposztás Z; Department of Surgery, Somogy County Teaching Hospital, Kaposvár, 7400, Hungary., Nagy G; Department of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, Kaposvár Campus, Kaposvár, 7400, Hungary. gabor.nagy.oh@gmail.com., Dezsényi B; Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, 1082, Hungary.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31435. Date of Electronic Publication: 2024 Dec 28.
DOI: 10.1038/s41598-024-83119-7
Abstrakt: Human alveolar echinococcosis (HAE), which is caused by the larval stage of the Echinococcus multilocularis tapeworm, is an increasing healthcare issue in Hungary. Among the 40 known cases in the country, 25 were detected in the last five years. Our study aimed to reveal the geographically underlying risk factors associated potentially with these cases. We investigated the spatial pattern and the impact of potential risk factors of HAE by cluster analysis, and local and global regression models. Also, a questionnaire survey on the patients' lifestyle was implemented. We found two HAE hyperendemic foci in the country with very dissimilar biotic and climatic features, and controversial impact of different environmental factors. Four factors, viz. forest cover (β = 0.291, p < 0.0001), surface soil wetness (β = - 0.157, p = 0.033), fox infection rate (β = 0.369, p < 0.0001) and socio-economic development (β = - 0.216, p = 0.009), proved important countrywide. The most forested and the least developed districts showed the highest HAE risk. Among the patients, kitchen gardening (67.86%) and dog ownership (67.86%) seemed the riskiest activities. Our models detected an anomaly in one of the poorest regions of Hungary where all risk factors behaved contrary to that of the neighboring areas. This phenomenon was supposed to be the result of under-detection of the disease, and it called attention to the urgent priority of knowledge dissemination to the public and the healthcare professionals.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Committee for Scientific and Research Ethics of the Medical Research Council (07-03-2024/BM/2130-3/2024). Patients participating in the questionnaire analysis were asked for informed consent before completing it. Their data was used in this study after their permission.
(© 2024. The Author(s).)
Databáze: MEDLINE
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