The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients.

Autor:	Zhang RL; Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China., Zhang X; Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for STD Control, Centers for Disease Control and Prevention, Nanjing, China., Du FZ; Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for STD Control, Centers for Disease Control and Prevention, Nanjing, China., Zhou QY; Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wu MZ; Department of Dermatology, The fifth People's Hospital of Suzhou, Suzhou, China., Ren JJ; Department of Dermatology, Xi 'an North Hospital, Xian, China., Zhou Z; Department of Dermatology, Xi 'an North Hospital, Xian, China., Li AL; Department of venereal Diseases, Dalian Dermatology Hospital, Dalian, China., Li DD; Department of Clinical Laboratory, West China Hospital, Sichuan University, Chengdu, China., Li HX; Department of Dermatology, First Hospital of Jilin University, Jilin, China., Yang LG; Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, China., Feng WL; Department of Dermatology, The Second Hospital of Shanxi Medical University, Taiyuan, China., Yang TC; Department of Clinical Laboratory, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, China., Li YY; Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Zhang J; Department of Dermatology, Guangxi Zhuang Autonomous Region Dermatology Hospital, Nanning, China., Wang SP; Department of Dermatology, Chongqing First People's Hospital, Chongqing, China., Luo Y; Department of infectious diseases, Chongqing Public health treatment Service center, Chongqing, China., Gu MS; Department of Dermatology, Nantong Fourth People's Hospital, Nantong, China., Yu XY; Department of Dermatology, Nanjing Second Hospital, Nanjing, China., Hu LH; Department of Clinical Laboratory, Zhejiang Institute of Dermatology Prevention and Treatment, Huzhou, China., Zhao JB; Department of Dermatology, Xuzhou First People's Hospital, Xuzhou, China., Ma YN; Department of Dermatology, Wuxi Second People's Hospital, Wuxi, China., Ma XW; Department of Dermatology, Angang Group General Hospital, Anshan, China., Zeng TX; Department of Dermatology, Jingzhou First People's Hospital, Jingzhou, China., Gao Y; Department of Dermatology, Tongji Medical College, The Central hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, China., Wang QQ; Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for STD Control, Centers for Disease Control and Prevention, Nanjing, China. wangqianqiunj@126.com.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31171. Date of Electronic Publication: 2024 Dec 28.
DOI:	10.1038/s41598-024-82477-6
Abstrakt:	Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023. This study was designed to explore clinical practices in the diagnosis and treatment of neurosyphilis. We proposed and validated a new set of diagnostic criteria across 782 cases, comparing three different NS criteria for diagnostic efficiency. Among the 782 patients analyzed, 410 were diagnosed with neurosyphilis, while 372 were not. The newly developed NS criteria demonstrated a sensitivity of 99.5% and a specificity of 94.6%, with the added benefit of being user-friendly. In subgroups categorized by neurological symptoms and syphilis stages, the new NS criteria also exhibited high sensitivity and specificity. Statistical analyses confirmed that the novel NS criteria performed comparably well to the expanded NS criteria. The novel NS criteria for HIV-negative patients exhibited high sensitivity and specificity, proving to be both effective and convenient for physicians to implement. Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was reviewed and approved by the Medical Ethics Committee of Institute of Dermatology, Chinese Academy of Medical Sciences, and National Center for STD Control, China Centers for Disease Control, in Nanjing, China (approval number: 2019-KY-020). The patients in this manuscript have given written informed consent to publication of their case details. (© 2024. The Author(s).)
Databáze:	MEDLINE
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