Association between antinuclear antibodies status and preterm birth in Japanese pregnant women: a prospective cohort study from Adjunct Study of the Japan Environment and Children's Study.

Autor: Fukushige M; Department of Nursing, Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto, Kumamoto, 862-0976, Japan. mfukushige@kumamoto-u.ac.jp.; Kumamoto University Regional Centre, The Japan Environment and Children's Study (JECS), 718, Medical Research Building, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. mfukushige@kumamoto-u.ac.jp., Lu X; Occupational and Community Health Nursing, School of Health Sciences, University of Occupational and Environmental Health School of Health Sciences, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan., Satoh M; Department of Human, Information and Life Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.; Department of Medicine, Kitakyushu Yahata-Higashi Hospital, 1-4-3 Higashida, Yahatahigashi-ku, Kitakyushu, Fukuoka, 805-0071, Japan., Oda M; Kumamoto University Regional Centre, The Japan Environment and Children's Study (JECS), 718, Medical Research Building, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan., Ohba T; Kumamoto University Regional Centre, The Japan Environment and Children's Study (JECS), 718, Medical Research Building, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan.; Department of Obstetrics and Gynecology, Faculty of Life Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan., Katoh T; Kumamoto University Regional Centre, The Japan Environment and Children's Study (JECS), 718, Medical Research Building, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan.; Department of Public Health, Faculty of Life Sciences, Kumamoto University, 1-1-1 Kuhonji, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan.
Jazyk: angličtina
Zdroj: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2024 Dec 28; Vol. 24 (1), pp. 879. Date of Electronic Publication: 2024 Dec 28.
DOI: 10.1186/s12884-024-07084-9
Abstrakt: Background: Antinuclear antibodies (ANA) are important biomarkers for the diagnosis of autoimmune diseases; however, the general population also tests positive at a low frequency, especially in women. Although the effects of various autoimmune diseases on pregnancy outcomes have been studied, the association of ANA with pregnancy outcomes in healthy individuals is unclear. Preterm birth (PTB), a major cause of neonatal death or long-term health problems, is a complex condition with a multifactorial etiology, and the underlying mechanism remains unclear. The present Adjunct Study aimed to determine the association between ANA and PTB in pregnant Japanese women based on a data analysis of the Japan Environment and Children's Study.
Methods: In a prospective cohort design, we analyzed the demographic and pregnancy outcome data of 1085 pregnant Japanese women who were recruited between January 2011 and March 2014 in the Kumamoto University target area. Demographic data were collected using self-administered questionnaires and physician records. A serum ANA titer of ≥ 1:40 was defined as positive. Statistical analysis was performed by logistic regression analysis with PTB as the objective variable.
Results: The PTB rate was significantly higher in those who were ANA-positive (adjusted odds ratio, 2.06; 95% confidence interval, 1.09-3.87) than in those who were not.
Conclusions: This study suggests that ANA positivity in the first trimester of pregnancy is associated with an increased risk of PTB.
Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Review Committee for Epidemiological Research of the Ministry of the Environment (approval number: 100910001) and the Ethics Review Committee of the affiliated institutions (approval number: 590). Written informed consent was obtained from all participants. This study was conducted in accordance with the Declaration of Helsinki and other national regulations and guidelines. To ensure protection of privacy rights, the data were de-linked from personal identifiers and strictly handled. Consent for publication: This study is not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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