Economic evaluation of tenofovir disoproxil fumarate prophylaxis to prevent mother-to-child transmission of Hepatitis B virus infection: evidence from a lower-middle income country.

Autor: Nguyen HT; Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University, Bangkok, 10400, Thailand.; University of Health Sciences, Vietnam National University Ho Chi Minh City, Binh Duong City, 820000, Vietnam., Chaikledkaew U; Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University, Bangkok, 10400, Thailand. usa.chi@mahidol.ac.th.; Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand. usa.chi@mahidol.ac.th., Hoang MV; Hanoi University of Public Health, Hanoi, 100000, Vietnam., Tran VQ; Military Hospital 175, Ho Chi Minh City, Vietnam., Thavorncharoensap M; Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University, Bangkok, 10400, Thailand.; Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand., Praditsitthikorn N; Division of Innovation and Research, Department of Disease Control, Ministry of Public Health, Nonthaburi, 11000, Thailand., Tran QD; Communicable Disease Control Division, General Department of Preventive Medicine, Vietnam Ministry of Health, Hanoi, 100000, Vietnam., Thakkinstian A; Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University, Bangkok, 10400, Thailand.; Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Jazyk: angličtina
Zdroj: BMC health services research [BMC Health Serv Res] 2024 Dec 28; Vol. 24 (1), pp. 1658. Date of Electronic Publication: 2024 Dec 28.
DOI: 10.1186/s12913-024-12152-z
Abstrakt: No cost-effectiveness information of preventive strategies for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) has existed for policy decision making. This study aimed to compare the cost-effectiveness of alternative strategies to prevent MTCT of HBV in Vietnam. Cost-utility analysis using a hybrid decision-tree and Markov model were performed from healthcare system and societal perspectives. Preventive strategies included HBV universal vaccination (S1), hepatitis B immunoglobulin (HBIG) for infants of mothers with HBeAg( +) (S2), HBIG for infants of mothers with HBsAg( +) (S3), tenofovir disoproxil fumarate (TDF) for mothers with high viral load (S4) and mothers with HBeAg( +) (S5), and the current practice (S6) with HBV vaccine in all infants and TDF for high viral load mothers. The current practice was dominant to all preventive strategies with interventions in only infants for both perspectives. In contrast, the strategies S4 and S5 were dominant to the current practice with incremental net monetary benefit varying from $33.94 to $70.64 under a healthcare system perspective and from $44.22 to $93.71 under a societal perspective. Addition of HBIG in infants born to mothers infected HBV and tenofovir prophylaxis for mothers with positive HBeAg was the most cost-effective strategy to prevent vertical transmission of HBV in Vietnam.
Competing Interests: Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board of School of Medicine, Vietnam National University Ho Chi Minh City (02/QĐ-IRB-VN01.017) and the Faculty of Dentistry and Faculty of Pharmacy, Mahidol University, Institutional Review Board (No.78.0319/EC.618). The need for informed consent for this study was waived by the ethics committees, as all data were obtained from published studies. All procedures performed in the study were in compliance with international guidelines for human research protection such as Declaration of Helsinki, the Belmont Report. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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