Regular Consumption of Black Tea Kombucha Modulates the Gut Microbiota in Individuals with and Without Obesity.

Autor: Costa MAC; Bioactive Compounds and Carbohydrates (BIOCARB) Research Group - Department of Food Science and Technology, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA., Silva Duarte VD; Faculty of Chemistry, Biotechnology, and Food Science, The Norwegian University of Life Sciences, P.O. Box 5003, 1432, Ås, Norway., Fraiz GM; Department of Nutrition and Health, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil; Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, Universidad de Navarra, Pamplona, Spain., Cardoso RR; Bioactive Compounds and Carbohydrates (BIOCARB) Research Group - Department of Food Science and Technology, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil., da Silva A; Public Health Epidemiology Graduate Program, Environmental and Health Education Laboratory. Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro - RJ, Brazil., Martino HSD; Department of Nutrition and Health, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil., Santos D'Almeida CTD; Laboratory of Bioactives, Food and Nutrition Graduate Program, Federal University of State of Rio de Janeiro - UNIRIO, Rio de Janeiro, RJ, Brazil., Ferreira MSL; Laboratory of Bioactives, Food and Nutrition Graduate Program, Federal University of State of Rio de Janeiro - UNIRIO, Rio de Janeiro, RJ, Brazil., Corich V; Department of Agronomy, Food Natural Resources, Animals, and Environment, Università degli Studi di Padova, Legnaro, Padova, PD, Italy., Hamaker BR; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA., Giacomini A; Department of Agronomy, Food Natural Resources, Animals, and Environment, Università degli Studi di Padova, Legnaro, Padova, PD, Italy., Bressan J; Department of Nutrition and Health, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil., Barros FAR; Bioactive Compounds and Carbohydrates (BIOCARB) Research Group - Department of Food Science and Technology, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil. Electronic address: fredbarros@ufv.br.
Jazyk: angličtina
Zdroj: The Journal of nutrition [J Nutr] 2024 Dec 26. Date of Electronic Publication: 2024 Dec 26.
DOI: 10.1016/j.tjnut.2024.12.013
Abstrakt: Background: Kombucha, a fermented beverage obtained from a Symbiotic Culture of Bacteria and Yeast (SCOBY), has shown potential in modulating gut microbiota, although no clinical trials have been done.
Objective: We aimed to evaluate the effects of regular black tea kombucha consumption on intestinal health in individuals with and without obesity.
Methods: A pre-post clinical intervention study was conducted lasting eight weeks. Forty-six participants were allocated into two groups: normal weight + black tea kombucha (n=23); and obese + black tea kombucha (n=23). Blood, urine, and stool samples were collected at baseline (T0) and after 8 weeks of intervention (T8).
Results: A total of 145 phenolic compounds were identified in the kombucha, primarily flavonoids (81%) and phenolic acids (19%). Kombucha favored commensal bacteria such as Bacteroidota and Akkermanciaceae, especially in the obese group. Subdoligranulum, a butyrate producer, also increased in the obese group after kombucha consumption (p=0.031). Obesity-associated genera Ruminococcus and Dorea were elevated in the obese group at baseline (p<0.05) and reduced after kombucha consumption, becoming similar to the normal weight group (Ruminococcus: obese T8 x normal weight T8: p=0.27; Dorea: obese T8 x normal weight T0: p=0.57; obese T8 x normal weight T8: p=0.32). Fungal diversity increased, with a greater abundance of Saccharomyces in both groups and reductions in Exophiala and Rhodotorula, particularly in the obese group. Pichia and Dekkera, key microorganisms in kombucha, were identified as biomarkers after the intervention.
Conclusions: Regular kombucha consumption positively influenced gut microbiota in both normal and obese groups, with more pronounced effects in the obese group, suggesting that it may be especially beneficial for those individuals.
Registration Id and Url: This study is registered on the Brazilian Clinical Trial Registry - ReBEC (UTN code U1111-1263-9550); available at .
Clinical Trial Statement: This study was conducted according to the guidelines established in the Declaration of Helsinki and the procedures were approved by the National Research Ethics Committee - CONEP/Brazil (registration no. 3.948.033). Written informed consent was obtained from all subjects. This study is registered on the Brazilian Clinical Trial Registry (ReBEC), available at (UTN code U1111-1263-9550).
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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