Is increased mutation driving genetic diversity in dogs within the Chornobyl exclusion zone?

Autor: Dillon MN; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States of America., Dickey AN; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America., Roberts RB; Department of Biological Sciences, North Carolina State University, Raleigh, NC, United States of America., Betz JA; Visiting Veterinarians International, Damascus, OR, United States of America., Mousseau TA; Department of Biological Sciences, University of South Carolina, Columbia, SC, United States of America., Kleiman NJ; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States of America., Breen M; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States of America.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, United States of America.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, United States of America.; Cancer Genetics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America.; Duke Cancer Institute, Duke University, Durham, NC, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Dec 27; Vol. 19 (12), pp. e0315244. Date of Electronic Publication: 2024 Dec 27 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0315244
Abstrakt: Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically close populations of these dogs. With this work, we investigate mutation as a possible driver of this genetic differentiation. First, we consider large-scale mutation by assessing the karyotypic architecture of these dogs. We then search for evidence of mutation through short tandem repeat/microsatellite diversity analyses and by calculating the proportion of recently derived alleles in individuals in both populations. Through these analyses, we do not find evidence of differential mutation accumulation for these populations. Thus, we find no evidence that an increased mutation rate is driving the genetic differentiation between these two Chornobyl populations. The dog populations at Chornobyl present a unique opportunity for studying the genetic effects of the long-term exposures they have encountered, and this study expands and builds on previous work done in the area.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Dillon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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