An Unusual Case of Nephrotic Range Proteinuria in a Short-Standing Type 1 Diabetic Patient with Newly Diagnosed Systemic Lupus Erythematosus: A Case Report and Literature Review.

Autor:	Dominguez Davalos M; Department of Nephrology, Hospital Cayetano Heredia, Lima 15002, Peru.; Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru., De La Flor JC; Department of Nephrology, Hospital Central Defense Gomez Ulla, 280467 Madrid, Spain.; Faculty of Medicine, Alcala de Henares University, 28805 Madrid, Spain., Bedia Castillo C; Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru.; Department of Rheumatology, Hospital Cayetano Heredia, Lima 15002, Peru., Lipa Chancolla R; Anatomic Pathology Department, Instituto Nacional de Salud del Niño, Lima 15082, Peru., Rodríguez Tudero C; Department of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain., Apaza J; Department of Nephrology, Hospital Rey Juan Carlos, 28933 Madrid, Spain., Zamora R; Department of Nephrology, Hospital Universitario General Villalba, 28400 Madrid, Spain., Cieza-Terrones M; Department of Nephrology, Hospital Cayetano Heredia, Lima 15002, Peru.; Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru.
Jazyk:	angličtina
Zdroj:	Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2024 Dec 16; Vol. 12 (4). Date of Electronic Publication: 2024 Dec 16.
DOI:	10.3390/medsci12040074
Abstrakt:	Background: Lupus podocytopathy (LP) is a non-immune complex-mediated glomerular lesion in systemic lupus erythematosus (SLE), characterized by the diffuse effacement of podocyte processes without immune complex deposition or with only mesangial immune complex deposition. LP is a rare cause of nephrotic syndrome in SLE patients with implications for prognosis and treatment. Case Report: We present the case of a 28-year-old woman with a medical history of type 1 diabetes mellitus (T1DM) who presented with lower limb edema, dyspnea, hypercholesterolemia, with nephrotic range proteinuria, without acute kidney injury, and laboratory findings compatible with auto-immune hemolytic anemia. They had negative infectious serology, positive antinuclear antibody (ANA), and an eye fundus examination showing diabetic retinopathy. A biopsy was performed to define the etiology of the renal involvement, which was compatible with LP. Following immuno-suppressive and antiproteinuric therapy, the patient evolved with the complete remission of the nephrotic syndrome. Conclusions: Lupus podocytopathy is an infrequent anatomopathological entity, so this case is presented as the first reported in Peru, and a literature review is made.
Databáze:	MEDLINE
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