| Autor: |
Silva-Reis A; Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil.; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil., Brill B; Leniado Medical Center, Divrei Khayim St. 16, Nethanya 4244916, Israel., Brandao-Rangel MAR; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil., Moraes-Ferreira R; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil., Melamed D; Department of Research and Development, Libi Pharm, Ben Gurion 70, Rechovot 7639461, Israel., Aquino-Santos HC; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil., Frison CR; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil., Albertini R; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil., Lopes-Martins RÁB; Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil., de Oliveira LVF; Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil., Paixao-Santos G; Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil., Oliveira CR; GAP Biotech Laboratory of Biotechnology and Bioinformatics, Rua Comendador Remo Cesaroni 223, São José dos Campos 12243-020, SP, Brazil., Abbasi A; Division of Respiratory and Critical Care Physiology and Medicine, Department of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W Carson St, CDCRC Building, Torrance, CA 90502, USA., Vieira RP; Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil.; Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil.; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Pedro Ernesto 240, São José dos Campos 12245-520, SP, Brazil. |
| Abstrakt: |
Beyond the common comorbidities related to obesity, such as type 2 diabetes and cardiovascular diseases, impaired lung function is already known, but whether the fat distribution (sub-cutaneous, visceral) affects the lung function and pulmonary immune response are poorly known. Few evidence has shown that visceral fat is associated with insulin resistance, low-grade inflammation, and reduced lung function. In the present study, the body composition and fat distribution were evaluated by multi-frequency octopolar bioimpedance. This study demonstrated a possible association of increased visceral fat with impaired lung function in obesity grade I (n = 28; 45.46 ± 10.38 years old) women that was not observed in normal weight (n = 20; 43.20 ± 10.78 years old) and in overweight women (n = 30; 47.27 ± 10.25 years old). We also identified a negative correlation in FVC% (R 2 = 0.9129; p < 0.0236), FEV1% (R 2 = 0.1079; p < 0.0134), PEF% (R 2 = 0.1673; p < 0.0018), and VC IN% (R 2 = 0.1330; p < 0.0057) in the obesity grade I group, clearly demonstrating that higher levels of visceral fat correlate with reduced lung function, but not with sub-cutaneous fat. In addition, for the first time, a negative correlation among anti-fibrotic protein klotho (R 2 = 0.09298; p < 0.0897) and anti-inflammatory IL-10 (R 2 = 0.1653; p < 0.0487) in plasma was observed, in contrast to increased visceral fat. On the contrary, in breath condensate, a positive correlation for adiponectin (R 2 = 0.5665; p < 0.0120), IL1-Ra (R 2 = 0.2121; p < 0.0544), and IL1-Beta (R 2 = 0.3270; p < 0.0084) was found. Thus, increased visceral fat directly influences the impairment of lung function and the systemic and pulmonary immune response of women with obesity grade I. |
