Alobar Holoprosencephaly in a Newborn: A Case Report of Prenatal Diagnosis and a Review of the Literature.

Autor:	Chafiq K; Neonatology, Souss Massa University Hospital Center, Agadir, MAR., Toumi K; Neonatology, Souss Massa University Hospital Center, Agadir, MAR., Khayi FE; Neonatology, Souss Massa University Hospital Center, Agadir, MAR., Daoudi A; Neonatology, Souss Massa University Hospital Center, Agadir, MAR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Nov 25; Vol. 16 (11), pp. e74462. Date of Electronic Publication: 2024 Nov 25 (Print Publication: 2024).
DOI:	10.7759/cureus.74462
Abstrakt:	Holoprosencephaly (HPE) is a severe and complex congenital brain malformation caused by a defect in the midline cleavage of the prosencephalon during early embryonic development. It is the most common prosencephalic malformation in humans and is categorized into three classical forms based on the severity of this cleavage defect: alobar, semilobar, and lobar HPE. A milder interhemispheric variant, called syntelencephaly, is also considered a form of HPE. This condition may arise from genetic, environmental, or teratogenic factors. Patients with HPE often present with facial dysmorphia, with severity generally correlating with the extent of brain malformation. HPE is diagnosed prenatally through ultrasound and brain magnetic resonance imaging (MRI). Through this case report and a review of the literature, we discuss the etiopathogenic and diagnostic aspects of HPE, along with the management of this congenital malformation, illustrated by the antenatal diagnosis of a newborn with alobar HPE, confirmed by brain MRI at 32 days of age. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Chafiq et al.)
Databáze:	MEDLINE
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