Assessment of in vitro interactions between delafloxacin and other antimicrobials against multi-drug resistant Pseudomonas aeruginosa strains.
| Autor: | Mataracı Kara E; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey., Çakmak SM; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.; Department of Pharmaceutical Microbiology, Istanbul University Institute of Graduate Studies in Health Sciences, Istanbul, Turkey., Er S; Department of Pharmacy, Yunus Emre Vocational School, Anadolu University, Eskişehir, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of chemotherapy (Florence, Italy) [J Chemother] 2024 Dec 26, pp. 1-7. Date of Electronic Publication: 2024 Dec 26. |
| DOI: | 10.1080/1120009X.2024.2445910 |
| Abstrakt: | Novel therapeutic interventions are required to address the critical antimicrobial resistance caused by multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections. This study examines the impact of combining delafloxacin with antibiotics on MDR-PA isolated from various samples. The minimum inhibitory concentrations (MICs) of delafloxacin, alone and in combination with other antibiotics, were determined against forty distinct MDR-PA isolates using the broth microdilution method. Time-kill curve assays were used to determine the bactericidal and synergistic effects of delafloxacin alone and in combination with other antibiotics in vitro against the selected five strains. Our studies showed delafloxacin exhibited four times greater in-vitro activity against MDR-PA strains than levofloxacin compared with both MIC |
| Databáze: | MEDLINE |
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