Aberrant bcl6 protein expression in patients with EMZL following recurrence or progression: case report of two cases.

Autor: Zhang M; Department of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China., Qu J; Department of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China., Guo W; Department of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China., Liu Y; Department of Hematology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China., Zhang W; Department of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China. 15165736627@163.com.
Jazyk: angličtina
Zdroj: Diagnostic pathology [Diagn Pathol] 2024 Dec 26; Vol. 19 (1), pp. 165. Date of Electronic Publication: 2024 Dec 26.
DOI: 10.1186/s13000-024-01593-z
Abstrakt: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) is an indolent B-cell lymphoma that can involve various anatomic sites. EMZL is derived from post-germinal center marginal zone B cells and typically lacks bcl-6 expression. Herein, we report two post-treatment cases of EMZL where unexpected bcl-6 protein expression was observed in specimens obtained following recurrence or progression. This contrasts with the primary specimens, which were negative for the bcl-6. Additionally, we confirm that the altered bcl6 expression observed in relapsed EMZL cases is independent of BCL6 gene rearrangement, as demonstrated by fluorescence in situ hybridization analysis. Relevant literature was reviewed and summarized to enhance the understanding of this phenomenon, particularly for pathologists.
Competing Interests: Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the research committee of Yantai Yantaishan Hospital (number: 2024069). The Yantai Yantaishan Hospital ethical committee exempted the informed consent of this study. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: