Changes in muscle-to-fat ratio are associated with lung function decline and airflow obstruction in the general population.

Autor: Kim E; Yonsei University College of Medicine, Seoul, Republic of Korea., Leem AY; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Jung JY; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim YS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Park Y; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 0mokfv@yuhs.ac.; Institute for Innovation in Digital Healthcare, Yonsei University, Seoul, Republic of Korea. 0mokfv@yuhs.ac.
Jazyk: angličtina
Zdroj: Respiratory research [Respir Res] 2024 Dec 26; Vol. 25 (1), pp. 444. Date of Electronic Publication: 2024 Dec 26.
DOI: 10.1186/s12931-024-03081-w
Abstrakt: Background: The long-term relationship between body composition and lung function has not yet been fully demonstrated. We investigated the longitudinal association between muscle-to-fat (MF) ratio and lung function among middle-aged general population.
Methods: Participants were enrolled from a community-based prospective cohort between 2005 and 2014. Lung function parameters (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV 1 ], and FEV 1 /FVC) and the MF ratio (total body muscle mass [kg]/fat mass [kg]) were assessed biannually via spirometry and bioelectrical impedance analysis, respectively.
Results: We followed up 4,712 participants (age 53.9 ± 7.9 years, men 45.8%) for 8 years. With an increase in MF ratio of 1, in men, the FVC increased by 43.9 mL, FEV 1 by 37.6 mL, and FEV 1 /FVC by 0.320%, while in non-smoking women, the FVC increased by 55.8 mL, FEV 1 by 44.3 mL, and FEV 1 /FVC by 0.265% (all P < 0.001). The MF ratio-decreased group showed further annual deterioration in lung function than the MF ratio-increased group (men: FVC - 44.1 mL vs. -28.4 mL, FEV 1 -55.8 mL vs. -39.7 mL, FEV 1 /FVC - 0.53% vs. -0.42%; non-smoking women: FVC - 34.2 mL vs. -30.3 mL, FEV 1 -38.0 mL vs. -35.2 mL; all P < 0.001, except FEV 1 in non-smoking women; P = 0.005). The odds ratio for the incidence of airflow obstruction according to the MF ratio was 0.77 (95% CI, 0.68-0.87) in men and 0.85 (95% CI, 0.74-0.97) in non-smoking women.
Conclusions: Long-term changes in the MF ratio are related to lung function deterioration and incidence of airflow obstruction in middle-aged general population.
Competing Interests: Declarations. Ethics approval and consent to participate: The Korea Centers for Disease Control and Prevention obtained written informed consent from all participants regarding the collection of their data. The Institutional Review Board of Severance Hospital approved the study protocol (4-2022-0558). All methods were performed in accordance with the approved protocol and with the relevant guidelines and regulations. Consent for publication: not applicable. Conflict of interest: None.
(© 2024. The Author(s).)
Databáze: MEDLINE
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