Prognostic implications of increased and final quantitative flow ratios in patients treated with drug-coated balloons physiological evaluation after DCB in de novo lesions.

Autor: Lin L; Beijing Anzhen Hospital, Capital Medical University, Anzhen road No.1, Beijing, China., Ding Y; Beijing Anzhen Hospital, Capital Medical University, Anzhen road No.1, Beijing, China., Tang Y; Peking University Third Hospital, Beijing, China., Wang G; Peking University Third Hospital, Beijing, China., Fu G; Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China., Wang L; Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Chen L; Fujian Medical University Affiliated Union Medical College Hospital, Fuzhou, China., Liu X; Inner Mongolia Autonomous Region People's Hospital, Huhehaote, China., Liu B; The Second Norman Bethune Hospital of Jilin University, Changchun, China., Chen H; Beijing Friendship Hospital, Capital Medical University, Beijing, China., Liu G; The First Hospital of Hebei Medical University, Shijiazhuang, China., Tang Q; Peking University Shougang Hospital, Beijing, China., Zeng Y; Beijing Anzhen Hospital, Capital Medical University, Anzhen road No.1, Beijing, China. yzeng_anzhen@163.com.
Jazyk: angličtina
Zdroj: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Dec 26; Vol. 24 (1), pp. 743. Date of Electronic Publication: 2024 Dec 26.
DOI: 10.1186/s12872-024-04413-w
Abstrakt: Background: Few studies investigated the implications of post-PCI QFR and post-PCI ΔQFR (absolute increase of QFR) in de novo lesions of small coronary disease after drug-coated balloon (DCB).
Objectives: We sought to investigate the prognostic implications of post-PCI QFR and post-PCI ΔQFR in patients who received DCB only.
Methods: Patients were divided according to the optimal cutoff value of the post-PCI QFR and the post-PCI ΔQFR. The primary outcome was major adverse cardiovascular events (MACE), including target vessel revascularization (TVR), cardiac death, and myocardial infarction (MI).
Results: The optimal cutoff values of QFR and ΔQFR for the MACE rate were 0.86 and 0.57, respectively. There were 175 patients (61.2%) with a high QFR (≥ 0.86) and 113 patients (39.5%) with a high ΔQFR (≥ 0.57) after PCI. The MACE rate was significantly higher in patients with a low QFR compared to a high QFR (5.7% vs. 27.0%, hazard ratio [HR]: 3.632, 95% confidence interval [CI]: 1.872 to 7.044, P < 0.001). The MACE rate was higher in patients with a low ΔQFR increase compared to those with high ΔQFR (4.4% vs. 20.2%, HR: 4.700, 95%CI: 2.430 to 9.089, P = 0.001). In multivariable model, a low post-PCI QFR and a low post-PCI ΔQFR was independent predictor of MACE (adjusted HR: 4.071, 95%CI: 2.037 to 8.135, P = 0.001).
Conclusions: After DCB in de novo lesions of small coronary disease, both post-PCI QFR and ΔQFR showed similar prognostic implications in MACE.
Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the ethical committee of Beijing Anzhen hospital and informed consent was provided by all of the patients according to hospital guidelines. All the experiment was conducted according to the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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