Endocrine-disrupting chemical, methylparaben, in environmentally relevant exposure promotes hazardous effects on the hypothalamus-pituitary-thyroid axis.

Autor: Azeredo DBC; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil., Sousa Anselmo D; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil., Falcão Veríssimo AC; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil., Souza LL; Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Brazil., Lisboa PC; Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Brazil., Soares P; i3S- Instituto de Investigação e Inovação em Saúde, Cell Signaling & Metabolism Group, Universidade do Porto, Portugal., Santos-Silva AP; Núcleo Multidisciplinar de Pesquisa em Biologia, Universidade Federal do Rio de Janeiro, campus Duque de Caxias, Brazil., Graceli JB; Laboratório de Toxicologia e Endocrinologia Celular, Departamento de Morfologia, Universidade Federal do Espírito Santo, Brazil; Animal Science, School of Agricultural Sciences, Southern Illinois University, Carbondale, IL, USA., Carvalho DP; Centro de Pesquisas em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Brazil., Magliano D; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil; Núcleo de Pesquisa em Morfologia e Metabolismo, Universidade Federal do Fluminense, Brazil., Miranda-Alves L; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Ciências Morfológicas, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address: leandro.alves@icb.ufrj.br.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2024 Dec 24, pp. 112444. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1016/j.mce.2024.112444
Abstrakt: Methylparaben (MP) belongs to the paraben class and is widely used as a preservative in personal care products, medicines, and some foods. MP acts as an endocrine disrupting chemical (EDC) on the hypothalamic-pituitary-thyroid (HPT) axis. However, the effects of MP have not yet been completely elucidated, as published results are scarce and controversial. The objective of this work was to evaluate the effects of subacute exposure to MP on the HPT axis of male rats. To achieve this, in this study the animals were divided into four experimental groups: control, MP3, MP30 and MP300 (3, 30 and 300 μg/kg/day, respectively). The rats were gavage for 14 days and sacrificed at the end of MP treatment. Our findings demonstrated that MP can promote important changes in thyroid morphology, including a decrease in follicular area, colloid area, epithelial area, and epithelial height, affecting the homeostasis of the HPT axis, and affecting the expression of genes related to hormonal biosynthesis. Furthermore, changes in interstitial collagen deposition were also demonstrated. Finally, we conclude that exposure to MP can be harmful to health, as it is involved in the dysregulation of the thyroid gland, affecting its morphophysiology, suggesting that even doses considered safe by current legislation can be dangerous and should be reconsidered.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Leandro Miranda-Alves reports financial support, administrative support, and equipment, drugs, or supplies were provided by Federal University of Rio de Janeiro. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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