Phenylpropanoid dimers from Chrysanthemum indicum with antioxidant effects via activating the Nrf2 signaling pathway.

Autor: Xue GM; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: xueguimin123@126.com., Xue JF; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China., Pan H; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China., Feng H; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China., Lei JW; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou, 450046, China., Chen H; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China., Feng WS; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China., Li GS; The Affiliated Taizhou Second People's Hospital of Yangzhou University, Taizhou, 225500, China. Electronic address: liguosheng1105@outlook.com., Wang Y; Henan Province Hospital of Traditional Chinese Medicine, No. 6, Dongfeng Road, Jinshui District, Zhengzhou City, Henan Province, 450002, China. Electronic address: livelywangyan@163.com.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2024 Dec 24; Vol. 232, pp. 114372. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1016/j.phytochem.2024.114372
Abstrakt: Five phenylpropanoid dimers chrysanthephenyls A-E, with the 1-O-1'-type (1) and 1-O-2'-type (2-5) ether bond linking modes, were isolated from the aerial parts of Chrysanthemum indicum. Among them, chrysanthephenyls D and E were two pairs of enantiomers, and chrysanthephenyl E was further resolved into its enantiomers (+)-chrysanthephenyl E and (-)-chrysanthephenyl E via chiral-phase HPLC. Their structures were characterized on the basic analysis of the spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR), and their absolute configurations were determined by DP4+ NMR analysis and ECD calculation method. The antioxidant activity of chrysanthephenyls A-E was determined by measuring their free radical scavenging effects using the trolox equivalent antioxidant activity (TEAC) assay, and chrysanthephenyls D and E showed 17 and 15 times better activity respectively than that of the positive control trolox. Moreover, a mechanistic study revealed that the potential antioxidant activity of chrysanthephenyl D decreased the level of reactive oxygen species (ROS) mediated via activating nuclear factor E2-related factor 2 (Nrf2) and its downstream oxidases.
Competing Interests: Declaration of competing interest The authors declare no competing financial interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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