The role of delta phase for temporal predictions investigated with bilateral parietal tACS.

Autor: Burke R; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany; Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany. Electronic address: r.burke@uke.de., Maÿe A; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany., Misselhorn J; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany., Fiene M; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany; Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany., Engelhardt FJ; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany., Schneider TR; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany; Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany., Engel AK; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany; Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
Jazyk: angličtina
Zdroj: Brain stimulation [Brain Stimul] 2024 Dec 24. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1016/j.brs.2024.12.1476
Abstrakt: Background: Previous research has shown that temporal prediction processes are associated with phase resets of low-frequency delta oscillations in a network of parietal, sensory and frontal areas during non-rhythmic sensory stimulation. Transcranial alternating current stimulation (tACS) modulates perceptually relevant brain oscillations in a frequency and phase-specific manner, allowing the assessment of their functional qualities in certain cognitive functions like temporal prediction.
Objective: We addressed the relation between oscillatory activity and temporal prediction by using tACS to manipulate brain activity in a sinusoidal manner. This enables the investigation of the relevance of low-frequency oscillations' phase for temporal prediction.
Methods: Delta tACS was applied over the left and right parietal cortex in two separate unimodal and crossmodal temporal prediction experiments. Participants judged either the visual or the tactile reappearance of a uniformly moving visual stimulus, which shortly disappeared behind an occluder. tACS was applied with six different phase shifts relative to sensory stimulation in both experiments. Additionally, a computational model was developed and analysed to elucidate oscillation-based functional principles for the generation of temporal predictions.
Results: Only in the unimodal experiment, the application of delta tACS resulted in a phase-dependent modulation of temporal prediction performance. By considering the effect of sustained tACS in the computational model, we demonstrate that the entrained dynamics can phase-specifically modulate temporal prediction accuracy.
Conclusion: Our results suggest that delta oscillatory phase contributes to unimodal temporal prediction. Crossmodal prediction may involve a broader brain network or cross-frequency interactions, extending beyond parietal delta phase and the scope of our current stimulation design.
Competing Interests: Declaration of Competing Interest ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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