| Autor: |
Yu ZN; Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea., Fan YJ; Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.; School of Medicine, Liaocheng University, Liaocheng 252000, China., Nguyen TV; Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea., Piao CH; Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.; Department of Pulmonary and Critical Care Medicine, Yantai Yuhuangding Hospital, Yantai 264000, China., Lee BH; Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea., Lee SY; Division of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea.; Food Biotechnology Program, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea., Shin HS; Division of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea.; Food Biotechnology Program, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea., Kim TG; Department of Bio-Convergence Science, Jeongup Campus of Jeonbuk National University, Jeongup 56212, Republic of Korea., Song CH; Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.; Institute for Medical Sciences, Jeonbuk National University, Jeonju 54896, Republic of Korea., Chai OH; Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.; Institute for Medical Sciences, Jeonbuk National University, Jeonju 54896, Republic of Korea. |
| Abstrakt: |
Undaria pinnatifida ( U . pinnatifida ) has long been a part of the human diet and medicine. Although U . pinnatifida has been reported to have immunomodulatory, anti-inflammatory, anti-diabetic and antibacterial activities, its specific effect on patients with combined allergic rhinitis and asthma syndrome (CARAS) has not been clarified. In this study, the anti-allergic and anti-inflammatory effects of U . pinnatifida extract (UPE) are investigated in a mouse model of ovalbumin (OVA)-induced CARAS. The oral administration of UPE inhibits allergic responses by reducing OVA-specific immunoglobulin levels. As a result, the symptoms of early reactions are also improved. UPE inhibits the accumulation of inflammatory cells and attenuates the expression of Th2 cytokines in both nasal and bronchoalveolar lavage fluid. Furthermore, UPE treatment inhibits the NF-κB/MAPK signaling pathway in lung homogenates. Additionally, UPE prevents shedding of the nasal mucosal epithelium, protects the integrity of the epithelium, enhances the expression of E-cadherin at the junction of epithelial cells, and inhibits the degradation of ZO-1 and occludin in the airway epithelium. In addition, UPE ameliorates dysfunction of the nasal epithelial barrier by enhancing antioxidant properties and downregulating the expression of the inflammatory factor IL-33. These results suggest that UPE may treat CARAS by modulating epithelial cell dysfunction and oxidative stress. |
