Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report.

Autor: Asad S; Baptist Medical Center, Jacksonville, FL, USA., Latifzai K; Rocky Mountain Regenerative Medicine, Boulder, CO, USA., Eliopoulos VT; Rocky Mountain Regenerative Medicine, Boulder, CO, USA., Oakley DS; WAVi Research, 3857 N Steele St Ste 1293, Denver, CO, 80205, USA., Pates J; Baseline Neuro, Vail, CO, USA., Towers G; WAVi Research, 3857 N Steele St Ste 1293, Denver, CO, 80205, USA. grace.towers@wavimed.com.
Jazyk: angličtina
Zdroj: Journal of medical case reports [J Med Case Rep] 2024 Dec 24; Vol. 18 (1), pp. 638. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1186/s13256-024-04972-8
Abstrakt: Background: Ketamine treatment presents a novel approach for addressing refractory conditions, such as major depressive disorder, suicidal ideation, and posttraumatic stress disorder, which often co-occur and pose significant challenges for clinicians. This study explores the clinical and electrophysiological outcomes of ketamine treatment in two cases, shedding light on its potential efficacy and mechanisms of action.
Case Presentation: The first case involves a 56-year-old Caucasian male with chronic posttraumatic stress disorder and suicidal ideation, and the second case involves a 52-year-old Caucasian female with treatment-resistant major depressive disorder. Both patients opted for ketamine treatment after years of unsuccessful interventions. The male patient received nine ketamine infusions over 18 months, while the female patient received five infusions over one month. Symptom improvement was accompanied by distinct electrophysiological changes, as observed through electroencephalogram and evoked electroencephalogram responses. These changes persisted for several months post-treatment, offering hope for individuals grappling with challenging chronic conditions.
Conclusion: Ketamine infusions resulted in significant and sustained symptomatic improvement in both cases, accompanied by distinct electrophysiological changes indicative of altered brain function. These findings highlight the potential of ketamine as an alternative treatment for refractory conditions, such as major depressive disorder and posttraumatic stress disorder, offering relief and functional recovery for certain patients. Further research is warranted to elucidate the underlying mechanisms and optimize treatment protocols.
Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the solutions institutional review board. Informed consent was obtained from all participants prior to their involvement in the study, and measures were taken to ensure confidentiality and privacy throughout the research process. Consent for publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests: DO and GT are paid consultants and employees of WAVi Co. (providers of the EEG equipment). No other authors have conflicts to report.
(© 2024. The Author(s).)
Databáze: MEDLINE
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