A case report of an M protein-negative patient with POEMS syndrome associated with renal involvement.

Autor: Liu W; Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518000, China., Zhou Y; Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518000, China., Li L; Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518000, China., Zhang F; Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518000, China., Xiong Z; Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518000, China., Hou S; Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518000, China. hssz2007@126.com.
Jazyk: angličtina
Zdroj: BMC nephrology [BMC Nephrol] 2024 Dec 24; Vol. 25 (1), pp. 472. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1186/s12882-024-03898-z
Abstrakt: Background: POEMS syndrome with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes is an uncommon plasma cell paraneoplastic syndrome involving multiple system. It is relatively rare in clinical practice, and renal involvement is a usual yet easily overlooked symptom.
Case Presentation: We successfully treated a patient with M protein-negative POEMS syndrome with membranoproliferative glomerulonephritis (MPGN) findings and thrombotic microangiopathic changes by comparing the level of Vascular endothelial growth factor (VEGF) in the serum and the changes in polyserositis before and after the patient's treatment.
Conclusion: POEMS syndrome clinically involves multiple systems and has complex symptoms. Because of the diversity of the disease manifestations, identification of atypical POEMS syndrome and timely intervention are important for patient survival and prognosis.
Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable for this case report. Consent for publication: Patient provided written informed consent for the publication of this case report. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: