The association between animal protein, plant protein, and their substitution with bladder cancer risk: a pooled analysis of 10 cohort studies.

Autor: Beigrezaei S; Department of Global Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands., Dianati M; International Agency for Research on Cancer World Health Organization, Lyon, France.; School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia., Salehi-Abargouei A; Nutrition and Food Security Research Center, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Fararouei M; Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran., Akbari-Beni A; Department of Cell & Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA., Brinkman M; Department of Epidemiology, Maastricht University, Universiteitssingel 40 (Room C5.570), Maastricht, 6229 ER, The Netherlands.; Department of Clinical Studies and Nutritional Epidemiology, Nutrition Biomed Research Institute, Melbourne, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia., White E; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Weiderpass E; International Agency for Research on Cancer World Health Organization, Lyon, France., Le Calvez-Kelm F; International Agency for Research on Cancer World Health Organization, Lyon, France., Gunter MJ; International Agency for Research on Cancer World Health Organization, Lyon, France., Huybrechts I; International Agency for Research on Cancer World Health Organization, Lyon, France., Liedberg F; Department of Urology, Skåne University Hospital, Malmö, Sweden.; Institution of Translational Medicine, Lund University, Malmö, Sweden., Skeie G; Department of Community Medicine, UIT The Arctic University of Norway, Tromsø, Norway., Tjonneland A; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Riboli E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Zeegers MP; Department of Epidemiology, Maastricht University, Universiteitssingel 40 (Room C5.570), Maastricht, 6229 ER, The Netherlands.; CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.; School of Cancer Sciences, University of Birmingham, Birmingham, UK., Wesselius A; Department of Epidemiology, Maastricht University, Universiteitssingel 40 (Room C5.570), Maastricht, 6229 ER, The Netherlands. anke.wesselius@maastrichtuniversity.nl.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2024 Dec 24; Vol. 64 (1), pp. 55. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1007/s00394-024-03551-3
Abstrakt: Purpose: Although total dietary protein intake has been associated with bladder cancer (BC) risk, the effect of the origin (plant or animal) and the substitutions remain to be understood. This study aimed to investigate the effect of total dietary protein, animal-based protein, plant-based protein, and their substitutions with each other on the risk of BC using a pooled analysis of 10 cohort studies.
Methods: The study was conducted within the "BLadder cancer Epidemiology and Nutritional Determinants" (BLEND) study, including 10 prospective cohort studies from several European countries, the United Kingdom, and the United States. Individual data from 10 prospective cohorts containing 434,412 participants (overall male/female ratio was almost 3:1) with a total of 4,224,643.8 person-years of follow-up was analyzed. Hazard ratios (HRs) and 95% confidence intervals (CIs) for BC risk for animal and plant-based protein substitutions of 30gram (g) per day (g/day) were estimated by multivariable adjusted HRs using Cox proportional hazards models.
Results: During 11.4 years of follow-up, among 434,412 participants (73.28% female), 1,440 new cases of BC were identified. After multivariable adjustment, no association was observed between the intake of total, animal-based protein, and plant-based protein and BC risk. Replacement of every 30 g/day of animal-based protein intake by the same amount of plant-based protein intake or vice versa was not associated with the risk of BC.
Conclusion: In conclusion, our study found no association between protein intake-whether from animal or plant sources-and the risk of BC. Substituting animal-based protein with plant-based protein, or the reverse, did not influence BC risk. Future studies are required to provide information on the link between animal- and plant-based proteins and BC risk.
Competing Interests: Declarations. Ethics approval and consent to participate: Each participating study has been approved by the local ethics committee. Informed consent was obtained from all individual participants included in each study. Conflict of interest: The authors declare that they have no conflict of interest. Disclaimer: Where authors are identified as personnel of the International Agency for Research on Cancer/ World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policies, or views of the International Agency for Research on Cancer/ World Health Organization.
(© 2024. The Author(s).)
Databáze: MEDLINE
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