Porous Nanocomposite Implants With Gold Nanoparticles for Plastic Surgery.

Autor: Korotych O; Department of Biochemical and Cellular and Molecular Biology, University of Tennessee at Knoxville, Tennessee, USA., Dybkova S; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Maletskyi A; Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine, Odesa, Ukraine., Rieznichenko L; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Kernosenko L; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Gruzina T; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Poltoratska T; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Artiomov O; Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine, Odesa, Ukraine., Pasmurtseva N; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Podolska V; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Vorotytskiy P; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine., Samchenko Y; Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2025 Jan; Vol. 113 (1), pp. e37851.
DOI: 10.1002/jbm.a.37851
Abstrakt: This study presents an innovative approach to improve implant biointegration and reduce implant-associated infections using porous poly(vinyl formal) nanocomposite matrices incorporated with gold nanoparticles and antimicrobial/anticancer drugs for plastic surgery applications. The porous matrices were characterized using physicochemical techniques and in vitro biochemical assays. The results demonstrated the biocompatibility of PVF nanocomposites and their potential for functionalization with various bioactive molecules and drugs, thereby enhancing their therapeutic efficacy. In vivo studies in rabbits revealed progressive replacement of implants with fibrous tissue, indicating successful biointegration with the surrounding soft tissues. Future research will focus on the long-term biocompatibility and functionalization of these nanocomposite implants for plastic surgery and explore their potential in other biomedical applications such as wound healing, tissue engineering, and scaffolds for cell growth and differentiation.
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Databáze: MEDLINE
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