Correlation between transforming growth factor-β1 (TGF- β1) with premature atherosclerosis in type 1 diabetes.
Autor: | Tjahjono HA; Doctoral program of Medical Science, Faculty of Medicine Universitas Brawijaya, Indonesia.; Saiful Anwar Hospital, Malang, Indonesia., Barlianto W; Pediatric Department, Faculty of Medicine Universitas Brawijaya, Malang, Indonesia., Handayani D; Nutrition Science Program, Medical Faculty, Universitas Brawijaya, Malang, Indonesia., Kalim H; Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. |
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Jazyk: | angličtina |
Zdroj: | ARYA atherosclerosis [ARYA Atheroscler] 2024; Vol. 20 (4), pp. 7-13. |
DOI: | 10.48305/arya.2024.11581.2125 |
Abstrakt: | Background: Type 1 diabetes (T1D) carries a significant risk of atherosclerosis as the main driver for cardiovascular events. Atherosclerosis is initiated by the activation of the endothelium by various risk factors through the inflammation process. The anti-inflammatory cytokine TGF-β1 may inhibit the development of atherosclerosis. Methods: In a cross-sectional study, a total of 40 patients aged 14.5±3.16 years old with T1D and 40 healthy controls aged 14.7±0.99 years old were involved. Common carotid artery IMT (cIMT) was measured by real-time M-echocardiography mode (Affinity 50G Philips) and Flow Mediated Dilatation (FMD), using high-resolution ultrasonography and Doppler flow characteristics. The TGF-β1 level was measured by indirect ELISA at Saiful Anwar Hospital Laboratory. Results: There were no differences in age, gender, Body Mass Index (BMI), duration of diabetes, renal function, or nutritional status between the T1D and healthy groups (p>0.05). A significant difference in cIMT was observed between the T1D group and the healthy group (0.567 ± 0.87 mm vs. 0.387 ± 0.57 mm, p = 0.000), FMD (7.17 ± 3.98 mm vs. 11.22 ± 5.48 mm, p = 0.000), and the level of TGF-β1 cytokine (39.83±13.51 vs. 73.67±15.34 pg/ml, p = 0.000). A significantly negative correlation between TGF-β1 and cIMT (p = 0.000; r = -0.685) and a significantly positive correlation between TGF-β1 and FMD (p = 0.000; r = +0.55) were found. Conclusion: Atherosclerosis is an inflammatory disease accelerated by diabetes. The inflammation process is more prominent in T1D patients. T1D patients show a decreased level of TGF-β1, increased measurement of cIMT (>0.5 mm), and a decreased measurement of FMD. Competing Interests: There is no conflict of interest. |
Databáze: | MEDLINE |
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