The Use of Single Pass Albumin Dialysis and Hemoadsorption in Management of Life-Threatening Amlodipine Overdose.

Autor: Hui WF; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong., Choi AWM; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong., Cheung WL; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong., Hon KL; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong., Ku SW; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong.
Jazyk: angličtina
Zdroj: Seminars in dialysis [Semin Dial] 2024 Dec 24. Date of Electronic Publication: 2024 Dec 24.
DOI: 10.1111/sdi.13236
Abstrakt: We report the successful application of single pass albumin dialysis (SPAD) and hemoadsorption (HA) in two teenagers with amlodipine poisoning. A 16-year-old girl with amlodipine overdose developed refractory shock and lactic acidosis despite multiple inotropes, calcium, insulin, and glucagon infusion. SPAD was initiated 18 h after the incident for 21 h. She improved dramatically and was able to wean off all inotropes 54 h after admission. Another 16-year-old girl required extracorporeal membrane oxygenation (ECMO) support after deliberate consumption of 1100-mg amlodipine. SPAD was initiated 13 h after the incident for 38 h, followed by two more sessions of HA using the Cytosorb column. All inotropes were stopped 18 h after terminating the HA, and ECMO was weaned off 28 h later. There were no major complications during the therapy. Our cases demonstrated that early extracorporeal removal can be considered as an adjunctive therapy in children with life-threatening amlodipine overdose.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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