[Development of a method for moxonidine quantification in blood and urine by high-performance liquid chromatography with tandem mass-selective detection].
| Autor: | Vasilenko AV; Chelyabinsk Regional Bureau of Forensic Medical Examination, Chelyabinsk, Russia., Melentyev AB; Chelyabinsk Regional Bureau of Forensic Medical Examination, Chelyabinsk, Russia., Dvorskaya ON; South Ural State Medical University, Chelyabinsk, Russia. |
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| Jazyk: | ruština |
| Zdroj: | Sudebno-meditsinskaia ekspertiza [Sud Med Ekspert] 2024; Vol. 67 (6), pp. 42-47. |
| DOI: | 10.17116/sudmed20246706142 |
| Abstrakt: | Objective: Development and validation of a sensitive and rapid method for moxonidine detection and quantification in blood and/or urine in clinical toxicology and forensic chemistry. Material and Methods: The method included the following stages: acetonitrile extraction, centrifugation, identification, and quantitative analysis of moxonidine in cadaveric blood and/or urine by high-performance liquid chromatography with a triple quadrupole mass spectrometer. Results: The method was validated by the following parameters: limit of detection, limit of quantification, linearity, trueness, and precision. Over the entire range of determined concentrations, the relative standard deviation did not exceed 6%. Conclusion: The obtained results allow future use of this method to detect cases of moxonidine poisoning. |
| Databáze: | MEDLINE |
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