Expansion microscopy reveals neural circuit organization in genetic animal models.
| Autor: | Behzadi S; New Jersey Institute of Technology, Federated Department of Biological Sciences, Newark, New Jersey, United States., Ho J; Albert Einstein College of Medicine, Departments of Genetics and Neuroscience, Bronx, New York, United States., Tanvir Z; Rutgers University, Departments of Cell Biology and Neuroscience and of Genetics, New Brunswick, New Jersey, United States., Haspel G; New Jersey Institute of Technology, Federated Department of Biological Sciences, Newark, New Jersey, United States., Freifeld L; Technion - Israel Institute of Technology, Faculty of Biomedical Engineering, Haifa, Israel., Severi KE; New Jersey Institute of Technology, Federated Department of Biological Sciences, Newark, New Jersey, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Neurophotonics [Neurophotonics] 2025 Jan; Vol. 12 (1), pp. 010601. Date of Electronic Publication: 2024 Dec 20. |
| DOI: | 10.1117/1.NPh.12.1.010601 |
| Abstrakt: | Expansion microscopy is a super-resolution technique in which physically enlarging the samples in an isotropic manner increases inter-molecular distances such that nano-scale structures can be resolved using light microscopy. This is particularly useful in neuroscience as many important structures are smaller than the diffraction limit. Since its invention in 2015, a variety of expansion microscopy protocols have been generated and applied to advance knowledge in many prominent organisms in neuroscience, including zebrafish, mice, Drosophila , and Caenorhabditis elegans . We review the last decade of expansion microscopy-enabled advances with a focus on neuroscience. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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