Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects.

Autor:	Lian YQ; Department of Critical Care Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China., Li PF; Department of Orthopaedics, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China., Guo Y; Pathology Department, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China., Tao YL; Department of Surgery ICU, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China., Liu YN; Department of Surgery ICU, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China., Liang ZY; Department of Critical Care Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China., Zhu SF; Physical Examination Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Dec 06; Vol. 15, pp. 1495394. Date of Electronic Publication: 2024 Dec 06 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1495394
Abstrakt:	Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients. As a complex ecosystem, recent research has highlighted the role of the intestinal microecology in transplantation, revealing its significant interplay with ischemia-reperfusion injury. This review explores the interaction between ischemia-reperfusion injury and intestinal microecology, with a special focus on how ischemia-reperfusion injury affects intestinal microecology and how these microecological changes contribute to complications after organ transplantation, such as infection and rejection. Based on a comprehensive analysis of current research advances, this study proposes potential strategies to improve transplant outcomes, offering guidance for future research and clinical practice. Competing Interests: The authors declare that this study was conducted in the absence of any commercial or financial relationship that could be interpreted as a potential conflict of interest. (Copyright © 2024 Lian, Li, Guo, Tao, Liu, Liang and Zhu.)
Databáze:	MEDLINE
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