Protective effects of different exercise modalities on oxidative stress in animal models of high intraocular pressure and diabetes.

Autor: Nau da Silva Piazza S; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil., Canteiro PB; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil., Tramontin NDS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil., Strapazzon G; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil., de Moraes Andrade V; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil., Muller AP; Department of Biochemistry, Post-Graduate Program in Biochemistry and Post-Graduate Program in Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil. Electronic address: alexandrep.muller@gmail.com.
Jazyk: angličtina
Zdroj: Experimental eye research [Exp Eye Res] 2024 Dec 20, pp. 110216. Date of Electronic Publication: 2024 Dec 20.
DOI: 10.1016/j.exer.2024.110216
Abstrakt: High intraocular pressure (HIOP) and high glucose levels are associated with oxidative stress. Although physical exercise protects against oxidative damage, its specific impact on eye health remains unclear. Thus, this study aimed to assess the impact of physical exercise on the oxidative status of whole eyes in male Swiss mice subjected to HIOP model and cafeteria diet (CD). In experiment one, mice were divided into sedentary, aerobic, and strength (four-week physical exercise) groups and subjected to an HIOP/ischemia model. In experiment two, mice were submitted to CD and voluntary physical exercise for 18 weeks, according to the following groups: sedentary control, sedentary CD, exercise control, and exercise CD. Experiment one revealed elevated 2',7'-dichlorodihydrofluorescein (DCFH) levels in aerobic group, which decreased in all groups after ischemia. Nitrite levels were decreased on strength than in sedentary group. The superoxide dismutase (SOD) activity did not change in all treatments. Although catalase (CAT) activity increased in aerobic and strength groups, and after ischemia in all groups. In experiment two, the sedentary CD group presented higher body weight than the other groups. DCFH levels were increased in the exercise control and reduced in the exercise CD compared with the other groups. CAT activity and sulfhydryl groups were decreased, while protein carbonylation was increased in the sedentary CD group compared with the other groups. Thus, these results suggested that physical exercise promoted antioxidant effects on eyes exposed to an HIOP model and CD.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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