Effect of vestibular training on cognitive functions in people with multiple sclerosis: A randomized controlled trial.

Autor: Darwish MH; Department of Physical Therapy for Neurology and Neurosurgery, Faculty for Physical Therapy, Cairo University, 12612, Egypt., El-Tamawy MS; Department of Neurology, Faculty of Medicine, Cairo University, Egypt., Ismail ME; Department of Physical Therapy for Neurology and Neurosurgery, Faculty for Physical Therapy, Cairo University, 12612, Egypt. Electronic address: manar.ismail@cu.edu.eg., Moustafa EBS; Department of Physical Therapy for Neurology and Neurosurgery, Faculty for Physical Therapy, Cairo University, 12612, Egypt., Khalifa HA; Department of Physical Therapy for Neurology and Neurosurgery, Faculty for Physical Therapy, Cairo University, 12612, Egypt; Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Jouf University, Al-Qurayyat, Saudi Arabia.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2024 Dec 18; Vol. 93, pp. 106239. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1016/j.msard.2024.106239
Abstrakt: Background: Cognitive dysfunction is prevalent but inadequately treated in people with multiple sclerosis (PwMS). Central vestibular functions are associated with multiple cognitive domains in PwMS, even when controlling for disability status. To our knowledge, the effectiveness of vestibular training on cognition in PwMS has never been explored. The study's purpose was to determine the effect of vestibular training on PwMS's cognitive functions.
Methods: Forty PwMS with relapsing-remitting MS, primarily fatigued, were randomly divided into two equal groups. The control group (GI) was treated with aerobic endurance exercises using stationary bicycle training. The study group (GII) was treated with aerobic endurance exercises as GI in addition to a designed vestibular training program. Outcome measures of cognition were assessed pre- and post-treatment using the Arabic version of Brief International Cognitive Assessment for MS (BICAMS-A) and serum Brain-derived neurotrophic factor (BDNF).
Results: Post-treatment, there was a significant increase of oral Symbol Digit Modalities Test (SDMT), California Verbal Learning Test II (CVLT-II), revised Brief Visuospatial retention Test (BVRT-R) of BICAMS-A and serum BDNF in both study and control groups. There was a significant increase in CVLT-II, BVRT-R of BICAMS-A and serum BDNF in the study group compared to the control group (P < 0.05).
Conclusion: Vestibular training is an effective and innovative approach for improving cognitive functions in PwMS.
Trial Registration: PACTR202311670782148.
Competing Interests: Declaration of competing interest No conflict of interest existed.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: