Ovarian response in preimplantation genetic testing for myotonic dystrophy type 1.

Autor:	Sonigo C; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, Université Paris-Saclay, Assistance Publique Hôpitaux de Paris, F-92140, Clamart, France. charlotte.sonigo@aphp.fr.; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, 157 Avenue de la Porte Trivaux, 92140, Clamart, France. charlotte.sonigo@aphp.fr., Ranisavljevic N; Département de Médecine de la Reproduction, CHU et Université de Montpellier, Montpellier, France., Guigui M; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, Université Paris-Saclay, Assistance Publique Hôpitaux de Paris, F-92140, Clamart, France., Anahory T; Département de Médecine de la Reproduction, CHU et Université de Montpellier, Montpellier, France., Mayeur A; Laboratoire d'Histologie-Embryologie-Cytogenetique CECOS, Hôpital Antoine Béclère, AP-HP, Université Paris Saclay, F-92140, Cedex, Clamart, France., Moutou C; Université de Strasbourg et Laboratoire de Diagnostic Préimplantatoire, Hôpitaux Universitaires de Strasbourg, 19 rue Louis Pasteur, 67303, Schiltigheim, France., Rongières C; Département de médecine de la reproduction, Centre Medico-Chirurgical et Obstetrical (CMCO), 19 rue Louis Pasteur, 67300, Schiltigheim, France., Reignier A; CHU Nantes, Nantes Université, Service de Medecine et Biologie de la Reproduction et Gynecologie Medicale, Nantes Université, Nantes, France., Leperlier F; CHU Nantes, Nantes Université, Service de Medecine et Biologie de la Reproduction et Gynecologie Medicale, Nantes Université, Nantes, France., Melaye G; CHU Nantes, Nantes Université, Service de Medecine et Biologie de la Reproduction et Gynecologie Medicale, Nantes Université, Nantes, France., Girardet A; PhyMedExp, University of Montpellier, Inserm, CNRS, CHU of Montpellier, Montpellier, France., Ray PF; CHU Grenoble Alpes, UF de Biochimie Génétique et Moléculaire, F-38000, Grenoble, France., Steffann J; Service de Génétique Moléculaire, Groupe Hospitalier Necker-Enfants Malades, AP-HP, Paris, France., Pirrello O; Département de médecine de la reproduction, Centre Medico-Chirurgical et Obstetrical (CMCO), 19 rue Louis Pasteur, 67300, Schiltigheim, France., Grynberg M; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, Université Paris-Saclay, Assistance Publique Hôpitaux de Paris, F-92140, Clamart, France.
Jazyk:	angličtina
Zdroj:	Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Dec 22. Date of Electronic Publication: 2024 Dec 22.
DOI:	10.1007/s10815-024-03324-1
Abstrakt:	Purpose: To evaluate ovarian stimulation response in couples undergoing preimplantation genetic testing (PGT-M) for myotonic dystrophy type 1 (DM1) METHODS: Retrospective, observational, multicentric study. Parameters of ovarian response and PGT-M outcomes were compared according to the DM1-affected patient (female or male). A total of 229 couples underwent at least one controlled ovarian hyperstimulation cycle for the PGT-M procedure. Overall, 678 COS cycles were started, leading to 560 cycles with oocyte retrievals and subsequent PGT-M analysis. Results: At the time of the first PGT-M attempt, affected DM1 females were 1 year older and their serum AMH level was significantly lower than that of the healthy partner of affected DM1 males. After higher starting and total doses of exogenous gonadotropins, the number of mature oocytes was not statistically different between both groups (9 [6-13] vs 9 [6-13] mature oocytes, p=0.73). The FORT index was similar in both groups (35.2% [19.2-52.8] vs 33.3% [19.6-50.0], p=0.09), suggesting that antral follicle responsiveness to FSH is not altered. The live birth rate per fresh embryo transfer was 23.8% in the affected females group and 27.6% for the affected males. Conclusion: After adapted controlled ovarian stimulation protocol and starting dose, a similar response (number of mature oocytes) and sensitivity (FORT index) was observed in DM1 females when compared to healthy partners of DM1 males undergoing PGT-M. Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
Externí odkaz:	Full text from SpringerLink