International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from a population-based cross-sectional disadvantaged populations eGFR epidemiology (DEGREE) study.

Autor:	Rutter CE; Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: Charlotte.Rutter1@lshtm.ac.uk., Njoroge M; Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK., Cooper P; Institute of Infection and Immunity, St George's University of London, UK; School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador., Dorairaj P; Public Health Foundation of India, New Delhi, India., Jha V; George Institute for Global Health, UNSW, New Delhi, India; School of Public Health, Imperial College, London, UK; Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India., Kaur P; Indian Institute of Science, Bengaluru, India., Mohan S; Public Health Foundation of India, New Delhi, India., Tatapudi RR; The Apollo University, Chittoor, Andhra Pradesh, India., Biggeri A; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Italy., Rohloff P; Center for Indigenous Health Research, Maya Health Alliance, Wuqu' Kawoq, Guatemala., Hathaway MH; Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois, Chicago, USA., Crampin A; Malawi Epidemiology and Intervention Research Unit (MEIRU), Malawi; University of Glasgow, UK., Dhimal M; Nepal Health Research Council, Kathmandu, Nepal., Poudyal A; Nepal Health Research Council, Kathmandu, Nepal., Bernabe-Ortiz A; CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Peru., O'Callaghan-Gordo C; Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain., Chulasiri P; Ministry of Health, Sri Lanka., Gunawardena N; WHO Regional Office, New Delhi, India., Ruwanpathirana T; Ministry of Health, Sri Lanka., Wickramasinghe SC; Ministry of Health, Sri Lanka., Senanayake S; Duke-NUS Medical School, Singapore., Kitiyakara C; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand., Gonzalez-Quiroz M; Department of Environmental and Occupational Health, UT School of Public Health San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA; Centre for Kidney and Bladder Health, University College London, London, UK; Wuqu' Kawoq Maya Health Alliance, Chimaltenango, Guatemala., Cortés S; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile., Jakobsson K; School of Public Health and Community Medicine, University of Gothenburg, Sweden; La Isla Network, Ada, Michigan, USA., Correa-Rotter R; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; National Autonomous University of Mexico, Mexico., Glaser J; La Isla Network, Ada, Michigan, USA., Singh A; Harvard University, USA., Hamilton S; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Nair D; Centre for Kidney and Bladder Health, University College London, London, UK; Department of Clinical Biochemistry, Royal Free Hospital, London, UK; Health Services Laboratories, London, UK., Aragón A; Wuqu' Kawoq Maya Health Alliance, Chimaltenango, Guatemala., Nitsch D; Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Robertson S; Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK., Caplin B; Centre for Kidney and Bladder Health, University College London, London, UK., Pearce N; Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
Jazyk:	angličtina
Zdroj:	Kidney international [Kidney Int] 2024 Dec 19. Date of Electronic Publication: 2024 Dec 19.
DOI:	10.1016/j.kint.2024.11.028
Abstrakt:	The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m 2 in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location. We included population-representative surveys conducted around the world that were either designed to estimate CKDu burden or were re-analyses of large surveys. There were 60,964 participants from 43 areas across 14 countries, with data collected 2007- 2023. The highest prevalence was seen in rural men in Uddanam, India (14%) and Northwest Nicaragua (14%). Prevalence above 5% was generally only observed in rural men, with exceptions for rural women in Ecuador (6%) and parts of Uddanam (6%‒8%), and for urban men in Leon, Nicaragua (7%). Outside of Central America and South Asia, prevalence was below 2%. Our observations represent the first attempts to estimate the prevalence of eGFR under 60 without commonly known causes of CKD around the world, as an estimate of CKDu burden, and provide a starting point for global monitoring. It is not yet clear what drives the differences, but available evidence supports a high general-population burden of CKDu in multiple areas within Central America and South Asia, although the possibility that unidentified clusters of disease may exist elsewhere cannot be excluded. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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