CHARACTERIZATION AND ANALYSIS OF THE BIOACTIVITY OF THE Piper rivinoides Kunth ESSENTIAL OIL AND ITS COMPONENTS MYRISTICIN AND ELEMICIN, AGAINST OPPORTUNISTIC FUNGAL PATHOGENS.
Autor: | Fonseca VJA; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE. Electronic address: victorjunobiomedico@gmail.com., Castro Dos Santos S; Universidade Regional de Blumenau - FURB, Rua Antônio da Veiga, 140 - Itoupava Seca, Blumenau, SC, Brasil., Carneiro JNP; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Dos Santos ATL; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., de Freitas MA; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., de Carvalho NKG; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Dos Santos Silva F; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Dos Santos AG; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Menêses AVS; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Farias NS; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Dos Santos RP; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Rebelo RA; Universidade Regional de Blumenau - FURB, Rua Antônio da Veiga, 140 - Itoupava Seca, Blumenau, SC, Brasil., Rau M; Universidade Regional de Blumenau - FURB, Rua Antônio da Veiga, 140 - Itoupava Seca, Blumenau, SC, Brasil., da Silva LE; Programa de Pós-Graduação em Desenvolvimento Territorial Sustentável, Setor Litoral, Universidade Federal do Paraná, Matinhos, PR, Brasil., Amaral WD; Universidade Federal do Paraná, Jardim das Américas, Curitiba, PR, Brasil., da Costa JGM; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., de Menezes IRA; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE., Morais-Braga MFB; Universidade Regional do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato- CE. |
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Jazyk: | angličtina |
Zdroj: | Microbial pathogenesis [Microb Pathog] 2024 Dec 19, pp. 107242. Date of Electronic Publication: 2024 Dec 19. |
DOI: | 10.1016/j.micpath.2024.107242 |
Abstrakt: | Candidiasis is an infectious disease caused by some fungi of the genus Candida. In Brazil, the incidence rate is higher than in European countries and the United States, and health problems occur mainly due to the virulence factors of the fungi, which have made treatment with commercial drugs difficult. Considering the context, plants rich in phenolic compounds, such as those of the genus Piper, have been studied due to their antimicrobial properties. Thus, the objective of this study was to isolate and characterize the essential oil of Piper rivinoides Kunth, as well as to analyze the bioactivity of this essential oil and the myristicin and elemicin isolates against opportunistic fungal pathogens. The broth microdilution method was used to identify the intrinsic activity of the isolated natural products alone and combined with fluconazole to obtain the 50% inhibitory concentration of the fungi (IC Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Ltd.) |
Databáze: | MEDLINE |
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