Association between maternal schizophrenia and risk of serious asthma exacerbations in childhood.

Autor: Pouget JG; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Cohen E; Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Hospital for Sick Children, Toronto, ON, Canada; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada., Ray JG; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Wilton AS; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada., Brown HK; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Department of Health & Society, University of Toronto Scarborough, Toronto, ON, Canada; Women's College Hospital and Research Institute, Toronto, ON, Canada., Saunders NR; Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Hospital for Sick Children, Toronto, ON, Canada; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada., Dennis CL; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada; Lawrence Bloomberg Faculty of Nursing, Toronto, ON, Canada., Holloway AC; Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Morrison KM; Department of Pediatrics, Centre for Metabolism, Obesity & Diabetes Research, McMaster University, Hamilton, ON, Canada., Hanley GE; Women's College Hospital and Research Institute, Toronto, ON, Canada; University of British Columbia, Vancouver, BC, Canada., Oberlander TF; University of British Columbia, Vancouver, BC, Canada., Bérard A; Centre Hospitalier Universitaire Sainte-Justine Research Center, Montreal, Quebec, Canada; Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada., Tu K; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; North York General Hospital, Toronto, ON, Canada; Toronto Western Hospital Family Health Team, University Health Network, Toronto, ON, Canada., Barker LC; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Women's College Hospital and Research Institute, Toronto, ON, Canada., Vigod SN; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; ICES (formerly Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Women's College Hospital and Research Institute, Toronto, ON, Canada. Electronic address: simone.vigod@wchospital.ca.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 Dec 20; Vol. 275, pp. 123-130. Date of Electronic Publication: 2024 Dec 20.
DOI: 10.1016/j.schres.2024.11.008
Abstrakt: Background and Hypothesis: While maternal schizophrenia is linked to chronic childhood medical conditions, little is known about the risk of acute asthma exacerbations among children whose mothers have schizophrenia. This population-based study used health data for all of Ontario, Canada to evaluate whether having a mother with schizophrenia was associated with increased risk of asthma exacerbations.
Study Design: The study cohort included 385,989 children diagnosed with asthma from age 2 years onward, followed from the time of their asthma diagnosis up to a maximum of age 19 years. Children whose biological mother was diagnosed with schizophrenia prior to the child's asthma diagnosis (n = 1407) were compared children whose mother was not (n = 384,582). Study outcomes were asthma-related hospitalization, and separately, asthma-related emergency department (ED) visit, each up to a maximum child age of 19 years. First exacerbations were evaluated using Cox proportional hazards models, and recurrent exacerbations by Andersen-Gill regression, adjusted for covariates.
Study Results: First hospitalization for an asthma exacerbation occurred in 76 (6.9 per 1000 person-years) vs. 19,679 (5.4 per 1000 person-years) children with and without maternal schizophrenia (adjusted hazard ratio [aHR] 1.21, 95 % CI 0.97-1.51). For first asthma-related ED exacerbations, the rates were 25.1 vs. 20.7 per 100 person-years (aHR 1.06, 95 % CI 0.93-1.21). The adjusted rate ratio (aRR) for recurrent hospitalizations for asthma exacerbations was 1.27 (95 % CI 0.98-1.66), and 1.11 (95 % CI 0.94-1.31) for recurrent asthma-related ED exacerbations.
Conclusions: This study did not observe meaningful differences in acute care utilization for asthma exacerbations among children whose biological mothers had schizophrenia.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships outside of the submitted work, which may be considered as potential competing interests: Simone Vigod and Gillian Hanley report royalties from UptoDate Inc for authorship of materials related to depression and pregnancy. Eyal Cohen reports a relationship with the Ontario Ministry of Health as an advisory board member on public drug policy for the Committee to Evaluate Drugs. Katherine Morrison reports an advisory board member relationship with Novo Nordisk Inc and Rhythm Pharmaceuticals. Alison Holloway reports an advisory board member relationship with Taylored Biotherapeutics. Natasha Saunders reports an honorarium from the BMJ Publishing Group Ltd and Archives of Diseases in Childhood. The other authors have no relevant conflicts of interest to they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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