Structure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.

Autor:	Cordova M; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, 6363 Alvarado Ct., San Diego, CA 92120, United States., Hau J; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States., Schadler A; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.; Department of Radiation Oncology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, United States., Wilkinson M; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, 6363 Alvarado Ct., San Diego, CA 92120, United States., Alemu K; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States., Shryock I; Department of Psychology, University of Oregon, Straub Hall, 1451 Onyx St., Eugene, OR, United States., Baker A; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States., Chaaban C; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States., Churchill E; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States., Fishman I; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, 6363 Alvarado Ct., San Diego, CA 92120, United States., Müller RA; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, 6363 Alvarado Ct., San Diego, CA 92120, United States., Carper RA; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Dec 03; Vol. 34 (12).
DOI:	10.1093/cercor/bhae457
Abstrakt:	Middle-aged and older adults with autism spectrum disorder may be susceptible to accelerated neurobiological changes in striato- and thalamo-cortical tracts due to combined effects of typical aging and existing disparities present from early neurodevelopment. Using magnetic resonance imaging, we employed diffusion-weighted imaging and automated tract-segmentation to explore striato- and thalamo-cortical tract microstructure and volume differences between autistic (n = 29) and typical comparison (n = 33) adults (40 to 70 years old). Fractional anisotropy, mean diffusivity, and tract volumes were measured for 14 striato-cortical and 12 thalamo-cortical tract bundles. Data were examined using linear regressions for group by age effects and group plus age effects, and false discovery rate correction was applied. Following false discovery rate correction, volumes of thalamocortical tracts to premotor, pericentral, and parietal regions were significantly reduced in autism spectrum disorder compared to thalamo-cortical groups, but no group by age interactions were found. Uncorrected results suggested additional main effects of group and age might be present for both tract volume and mean diffusivity across multiple subcortico-cortical tracts. Results indicate parallel rather than accelerated changes during adulthood in striato-cortical and thalamo-cortical tract volume and microstructure in those with autism spectrum disorder relative to thalamo-cortical peers though thalamo-cortical tract volume effects are the most reliable. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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