Response of circulating fatty acid binding protein 4 concentration to low-intensity acute aerobic exercise is amplified in an exercise duration-dependent manner in healthy men.
| Autor: | Numao S; Department of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, 1 Shiromizu, Kanoya, Kagoshima, 891-2393, Japan. numashige@nifs-k.ac.jp., Uchida R; Health and Sports Promotion Division, Sports Innovation Organization, National Institute of Fitness and Sports in Kanoya, 1 Shiromizu, Kanoya, Kagoshima, 891-2393, Japan., Nakagaichi M; Department of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, 1 Shiromizu, Kanoya, Kagoshima, 891-2393, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of physiological anthropology [J Physiol Anthropol] 2024 Dec 20; Vol. 43 (1), pp. 31. Date of Electronic Publication: 2024 Dec 20. |
| DOI: | 10.1186/s40101-024-00379-y |
| Abstrakt: | Background: Circulating fatty acid-binding protein 4 (FABP4) influences cardiovascular disease and glucose metabolism. Acute aerobic exercise increases circulating FABP4 concentrations, but the factors underlying this effect in humans are unclear. We investigated the effect of exercise duration on circulating FABP4 concentrations in healthy men. Methods: This randomized crossover study enrolled healthy young men randomly assigned to two trials, short-duration (SE) and long-duration (LE) aerobic exercises trials. Both involved acute aerobic exercise followed by 60 min of bed rest. The exercise intensity was the same (40% peak oxygen uptake); however, the duration was 40 and 70 min for the SE and LE trials, respectively. Venous blood samples were collected to measure hormones, metabolites, and FABP4 concentrations. Results: Twelve healthy young men completed both trials. Changes in hormone levels did not differ significantly between the SE and LE trials (p > 0.05). However, the circulating FABP4 concentration increased significantly only in the LE trial immediately after exercise (p = 0.018). It increased significantly 30-60 min post-exercise in both the SE and LE trials (p < 0.018), with the extent of the increase being significantly higher in the LE trial than in the SE trial (p < 0.001). In each trial, the total incremental area under the curve of circulating FABP4 concentration was significantly positively correlated with body fat percentage (SE trial: r Conclusion: Our findings suggest that exercise duration is associated with the magnitude of increased FABP4 secretion into the blood circulation. Body fat accumulation may also be involved in the magnitude of FABP4 secretion induced by acute aerobic exercise. Trial Registration: The study was pre-registered with the University Hospital Medical Information Network Center (UMIN), a clinical trial registration system (ID: UMIN000051068). Competing Interests: Declarations. Ethics approval and consent to participate: The study conformed to the principles outlined in the Helsinki Declaration and was approved by the ethics committee of the National Institute of Fitness and Sports in Kanoya (Approval number: 22–1-72). The purpose, design, and risks of this study were explained to all the participants, and each participant provided written informed consent. Consent for publication: This is not applicable as the study does not have individual data. Competing interests: The authors declare that they have no competing interests. (© 2024. The Author(s).) |
| Databáze: | MEDLINE |
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