The impact of obesity on sleep, pulmonary and chest wall restriction in Osteogenesis Imperfecta: a pilot study.

Autor: De Amicis R; Department of Food, Environmental and Nutritional Sciences (DeFENS), International Center for the Assessment of Nutritional Status and the Development of Dietary Intervention Strategies (ICANS-DIS), University of Milan, 20133, Milan, Italy.; Obesity Unit and Laboratory of Nutrition and Obesity Research, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20145, Milan, Italy., Landoni V; Valduce Hospital - Villa Beretta Rehabilitation Center, 23845, Costa Masnaga, Lecco, Italy., Bertoli S; Department of Food, Environmental and Nutritional Sciences (DeFENS), International Center for the Assessment of Nutritional Status and the Development of Dietary Intervention Strategies (ICANS-DIS), University of Milan, 20133, Milan, Italy.; Obesity Unit and Laboratory of Nutrition and Obesity Research, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20145, Milan, Italy., Sartorio A; Experimental Laboratory for Auxo-Endocrinological Research, IRCCS Istituto Auxologico Italiano, 28824, Piancavallo - Verbania, Italy., Aliverti A; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 20133, Milan, Italy., LoMauro A; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 20133, Milan, Italy. antonella.lomauro@polimi.it.
Jazyk: angličtina
Zdroj: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2024 Dec 20; Vol. 19 (1), pp. 479. Date of Electronic Publication: 2024 Dec 20.
DOI: 10.1186/s13023-024-03489-z
Abstrakt: Introduction: Osteogenesis Imperfecta (OI) is characterised by brittle bones, severe skeletal deformities, low sleep quality, and restricted breathing. We aimed to distinguish how disease and obesity affect these results.
Methods: According to BMI, we considered four groups of peer adults (median age: 35.0 years): 13 subjects affected by moderate or severe OI without obesity (OIno), 14 affected by moderate or severe OI with obesity (OIob), 10 without obesity not affected by OI (OB) and 10 without obesity not affected by OI.
Results: Obstructive Sleep Apnoea Syndrome was diagnosed in 4 OIno (30%) and 9 OIob (64%). Restricted lung pattern (z-score of total lung capacity < - 1.64) was diagnosed in 10 OIno (77%); 9 OIob (65%), and 1 OB (10%) subjects. In the seated position, OIob breathed with reduced tidal volume and higher respiratory rate, resulting in hypoventilation. Both OIno and OIob were characterised by rapid and shallow breathing and lower ribcage expansion (negative in 3 (23%) OIno and 3 (21%) OIob). In the supine position, the ventilatory pattern was similar among the four groups, while both OIno and OIob were characterised by reduced ribcage contribution, which was negative in 6 (46%) OIno, 11 (78%) OIob and 1 (10%) OB.
Conclusions: This is a pilot study on a small sample, the findings and conclusions apply only to this study population. The preliminary results suggest that in subjects with moderate or severe OI per se implies (1) a 30% prevalence of obstructive sleep apnoea syndrome, (2) a restricted lung pattern, (3) a lower ribcage expansion, and (4) rapid and shallow breathing in the seated position. The additional impacts of obesity on OI seem to determine (1) a higher incidence of obstructive sleep apnoea syndrome, (2) hypoventilation in the seated position, and (3) a higher incidence of paradoxical breathing lying supine. Reversing obesity in OI is even more challenging as knowledge of the diet and the physical activity suited for these patients is still scarce.
Competing Interests: Declarations. Ethics approval and consent to participate: The study was conducted according to the statement of the Declaration of Helsinki and approved by the Ethical Board Committee of Politecnico di Milano, Italy (n. 47/2021) and of Istituto Auxologico Italiano, Milan, Italy (research code: 01C307-2013; acronym: POSTVOLOB). All patients or parents gave their informed consent to participate. Consent for publication: All the subjects in Fig. 1 have given their written consent for the publication of identifiable details (i.e.: photographs). Competing interests: The authors have no conflict of interest to declare.
(© 2024. The Author(s).)
Databáze: MEDLINE
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