Coenzyme Q10 Attenuates Kidney Injury Induced by Titanium Dioxide Nanoparticles and Cadmium Co-exposure in Rats.

Autor: Abd-Elhakim YM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt. yasmina_forensic@hotmail.com., Hashem MMM; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12613, Egypt., Abo-El-Sooud K; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12613, Egypt., El-Metawally AE; Pathology Department, Animal Reproduction Research Institute, Giza, 3514805, Egypt., Hassan BA; Pharmacology Department, Faculty of Pharmacy, Future University, Cairo, 11835, Egypt. Bayan.saffaf@fue.edu.eg.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Dec 21. Date of Electronic Publication: 2024 Dec 21.
DOI: 10.1007/s12011-024-04469-x
Abstrakt: This study examined the possible defensive role of coenzyme Q10 (CQ10) against the impact of cadmium (Cd) and titanium dioxide nanoparticle (TNP) exposure on rat kidneys. Distilled water (1 mL/rat), corn oil (1 mL/rat), 10 mg CQ10/kg b.wt, 50 mg TNP/kg b.wt, 5 mg Cd/kg b.wt, TNP + Cd, or TNP + Cd + CQ10 was administered orally to seven groups of 70 male Sprague Dawley rats for 60 days. The findings demonstrated that TNP and/or Cd exposure considerably raised serum levels of several renal damage products, disturbed electrolyte balance including sodium, potassium, and calcium, decreased antioxidant enzyme concentration in the kidneys, and elevated malondialdehyde. In addition, rats exposed to TNP and/or Cd had significantly higher levels of renal titanium and Cd. In addition, rats exposed to TNP and/or Cd showed significant histopathological lesions and collagen deposition as revealed by H and E and Masson trichrome staining, respectively. The kidneys were severely damaged by the combined effects of TNP and Cd, although CQ10 greatly mitigated these effects. According to the study, exposure to TNP and Cd can damage the kidneys' function and structure, especially when combined. However, CQ10 can protect against TNP and Cd's nephrotoxic effects.
Competing Interests: Declarations. Ethical Approval: Per the following regulations: the National Research Council’s Guide for the Care and Use of Laboratory Animals, the EU Directive 2010/63/EU for animal experiments, and the UK Animals (Scientific Procedures) Act, 1986 and associated guidelines, all animal experiments were permitted by the Ethics Committee of the Faculty of Veterinary Medicine, Cairo University, Egypt (Approval no. VET CU 2009 2022462). Consent to Participate: Not applicable. Consent to Publish: Not applicable. Competing Interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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