Oral epithelial dysplasia with lichenoid features shares proteomic overlap with oral epithelial dysplasia without lymphocytic immune response.

Autor: Lorenzo-Pouso AI; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Pérez-García E; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Bravo SB; Proteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela, Santiago de Compostela, Spain., Coppini M; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy., França-Vieira-E-Silva F; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Chamorro-Petronacci CM; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Caponio VCA; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Padín-Iruegas ME; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Lafuente-Ibañez-de-Mendoza I; Department of Stomatology. University of the Basque Country (UPV/EHU), Leioa, Spain., Gándara-Vila P; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Pérez-Sayáns M; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Institute of materials of Santiago de Compostela (iMATUS). Avenida do Mestre Mateo, A Coruña, Spain. Electronic address: mario.perez@usc.es., Blanco-Carrión A; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1016/j.oooo.2024.10.085
Abstrakt: Objective: This study investigates the proteomic profiles of oral epithelial dysplasia with lichenoid features (OEDwithLF) and evaluates its relevance as a histopathological feature for lichenoid mucositis (LM) through differential proteomic characterization.
Study Design: SWATH-MS proteomic profiling was conducted on FFPE samples from 6 OEDwithLF, 5 OED cases without associated lymphocytic infiltration, and 5 LM cases. Protein expression levels were quantified and compared. In silico analysis examined the biological and molecular functions of dysregulated proteins.
Results: A total of 460 proteins were identified. Unsupervised clustering revealed significant differences between LM and OEDwithLF, with fewer differences observed between OEDwithLF and OED. Bioinformatic analysis indicated dysregulated proteins are involved in nucleic acid binding, ribosome function, and developmental biology. Key potential biomarkers include KRT17, LYSC, CAL5, and CRNN.
Conclusions: The proteomic profile of OEDwithLF is similar to OED without associated lymphocytic infiltration, but significantly different from LM. OED is relevant in lichenoid tissues, and its proteomic changes can be detected. Although OED may coexist with interface mucositis, it is not a defining feature of LM. This challenges the exclusion of epithelial dysplasia from lichenoid diagnoses. Based on this hypothesis-generating study, further investigation is warranted.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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