Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department.

Autor: Robbins B; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA. Electronic address: blake.robbins@uky.edu., Almassalkhi L; Atrium Health Wake Forest Baptist, 1 Medical Center Blvd, Winston-Salem, NC, 27157, USA., Baum R; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA., Blackburn M; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA., Davis J; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA., Edwards L; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA., Hile G; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA., Olney W; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA., Weant K; University of South Carolina College of Pharmacy, 715 Sumter St, Columbia, SC, 29208, USA., Metts E; University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA.
Jazyk: angličtina
Zdroj: The American journal of emergency medicine [Am J Emerg Med] 2024 Dec 08; Vol. 89, pp. 78-84. Date of Electronic Publication: 2024 Dec 08.
DOI: 10.1016/j.ajem.2024.12.004
Abstrakt: Traumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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