Functional Neurological Disorder and Autism Spectrum Disorder: A Complex and Potentially Significant Relationship.

Autor: Gonzalez-Herrero B; Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Bellaterra, Spain.; Neurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, UK.; Queen's Hospital, Barking, Havering and Redbridge University Hospitals, Romford, UK., Happé F; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Nicholson TR; Neuropsychiatry Research & Education Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Morgante F; Neurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, UK., Pagonabarraga J; Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Bellaterra, Spain.; Instituto de Investigación Biomédica de Sant Pau, Barcelona, Spain.; Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Deeley Q; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Autism Unit, South London and Maudsley NHS Foundation Trust, London, UK., Edwards MJ; Department of Clinical and Basic Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2024 Dec; Vol. 14 (12), pp. e70168.
DOI: 10.1002/brb3.70168
Abstrakt: Introduction: Functional neurological disorder (FND) and autism spectrum disorder (ASD) are two complex neuropsychiatric conditions that have been historically classified within psychiatric domains, resulting in a lack of extensive research, insufficient clinical recognition, and persistent societal stigma. In recent years, there has been an increasing recognition among professionals and affected individuals of their possible overlap. This review explores the potential clinical and mechanistic overlap between FND and ASD, with particular attention to shared symptoms across sensory, motor, and psychiatric domains.
Methods: We conducted a narrative analysis utilizing the PubMed, CINAHL, MEDLINE, and ScienceDirect databases from inception to June 2024. The search employed specific MeSH terms related to ASD and FND. Given the limited data availability, we included all relevant articles that explored the potential connections between FND and ASD, focusing on established findings and theoretical hypotheses areas.
Results: Scientific evidence indicates that FND and ASD may co-occur more frequently than previously acknowledged and with notable overlaps in their clinical presentations and pathophysiology. Theoretical models that have been applied to FND and ASD, such as the Bayesian brain theory and the tripartite model of autism, may provide valuable insights into the intersection of these conditions. Although much of the current evidence remains speculative, it underscores the need for hypothesis-driven research to investigate these potential connections further.
Conclusion: ASD and FND are heterogeneous conditions that appear to co-occur in a subset of individuals, with overlapping symptomatology and possibly shared underlying mechanisms. This hypothesis-generating review emphasizes the need for further research to better understand these links, ultimately aiming to improve clinical recognition and develop targeted interventions that enhance the quality of life for affected individuals.
(© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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