Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery.

Autor: Mansoor R; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Barkat K; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Faculty of Health Sciences, Equator University of Science and Technology, Masaka, Uganda., Anjum I; Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Aamir M; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Badshah SF; Department of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch Rawalakot, Azad Kashmir, Pakistan., Ullah R; Department of Pharmacognosy College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Iqbal Z; Department of Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Raza MA; Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Prague, Czech Republic.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Dec 20; Vol. 19 (12), pp. e0309101. Date of Electronic Publication: 2024 Dec 20 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0309101
Abstrakt: Free radical polymerization technique was used to formulate Poloxamer-188 based hydrogels for controlled delivery. A total of seven formulations were formulated with varying concentrations of polymer, monomer ad cross linker. In order to assess the structural properties of the formulated hydrogels, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were carried out. To assess the effect of pH on the release of the drug from the polymeric system, drug release studies were carried in pH 1.2 and 7.4 and it was found that release of the drug was significant in pH 7.4 as compared to that of pH 1.2 which confirmed the pH responsiveness of the system. Different kinetic models were also applied to the drug release to evaluate the mechanism of the drug release from the system. To determine the safety and biocompatibility of the system, toxicity study was also carried out for which healthy rabbits were selected and formulated hydrogels were orally administered to the rabbits. The results obtained suggested that the formulated poloxamer-188 hydrogels are biocompatible with biological system and have the potential to serve as controlled drug delivery vehicles.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Mansoor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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