Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats.

Autor: Keremane V; Dept. of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Kamala H; Dept. of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, India., Halami P; Dept. of Microbiology & Fermentation Technology, CSIR-Central Food Technological Research Institute, Mysore, 570020, India., Talahalli R; Dept. of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, India. ramaprasad@cftri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. ramaprasad@cftri.res.in.
Jazyk: angličtina
Zdroj: Metabolic brain disease [Metab Brain Dis] 2024 Dec 20; Vol. 40 (1), pp. 75. Date of Electronic Publication: 2024 Dec 20.
DOI: 10.1007/s11011-024-01509-2
Abstrakt: The common practice of reusing deep-fried oil may derange the ability of the brain to counter free radicals and inflammatory responses and can adversely alter neurobehavioral changes. In this study, we elucidated the modulatory potentials of Lactobacillus fermentum MCC2760 (LF) on neurobehavioral changes induced by dietary intake of oxidized oils. Female Wistar rats were fed with AIN-76 diets containing native sunflower oil (N-SFO), native canola oil (N-CNO), heated sunflower oil (H-SFO), heated canola oil (H-CNO), heated sunflower oil with probiotic (H-SFO + LF) or heated canola oil with probiotic (H-CNO + LF} for 60 days. After 60 days of feeding, they were mated with adult male rats. Upon mating confirmation, pregnant dams were continued on their respective diets until delivery. After delivery and post-lactation, F2 generation males (n = 6) were continued on a diet similar to their mothers for 60 days. Memory parameters [Morris water maze, Y-maze (spontaneous alteration), and novel object recognition test], locomotor skills and endurance (open field test and rotarod test), and anxiety test (elevated plus maze) were assessed in F2 generation males weighing 270 ± 10 g. Compared to their respective controls, heated oil-fed rats showed a significant (p < 0.05) decrease in memory and motor coordination skills, whereas a significant (p < 0.05) increase in anxiety-like behavior. However, administration of LF (10 9 CFU/day/rat) ameliorated the heated oil-induced neurobehavioral changes. Hence, the present study establishes that long-term consumption of thermally oxidized oil is detrimental to critical brain functions, including cognitive attributes. Dietary supplementation of probiotics may effectively counter the oxidized oil-induced cognitive loss.
Competing Interests: Declarations. All authors declare no conflicts of financial interest related to this submission, and no related manuscripts are in press. Ethical approval: The animal procedures were approved (CFT/IAEC/254/2021) and monitored by the Institutional Animal Care and Use Committee of CSIR-CFTRI, Mysore, India. All the experiments were performed according to the CPCSEA (Committee for Control and Supervision of Experiments on Animals) guidelines (CPCSEA Reg No: 49/ReBi/S/99/CPCSEA). Consent to participate: Not applicable. Consent for publication: All the authors have read the manuscript and have approved it for submission to the journal. We understand that this information will be freely available online and accessible to the general public. We confirm that once published, it cannot be removed from the published record except in exceptional circumstances. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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