Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease.

Autor: Lolescu BA; Doctoral School Medicine, Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania., Furdui-Lința AV; Doctoral School Medicine, Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Department III Functional Sciences-Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania., Ilie CA; Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Department III Functional Sciences-Chair of Public Health & Sanitary Management, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania., Sturza A; Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Department III Functional Sciences-Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania., Zară F; Department II Microscopic Morphology-Chair of Histology, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Department of Pathology, Timisoara Municipal Emergency Clinical Hospital, Timișoara, Romania., Muntean DM; Center for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.; Department III Functional Sciences-Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Timișoara, Romania., Blidișel A; Department of Surgery I-Clinic of Surgical Semiotics & Thoracic Surgery, Center for Hepato-Biliary and Pancreatic Surgery, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Sq., No.2, 300041, Timișoara, Romania. blidy@umft.ro., Crețu OM; Department of Surgery I-Clinic of Surgical Semiotics & Thoracic Surgery, Center for Hepato-Biliary and Pancreatic Surgery, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Sq., No.2, 300041, Timișoara, Romania.
Jazyk: angličtina
Zdroj: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Dec 20. Date of Electronic Publication: 2024 Dec 20.
DOI: 10.1007/s11010-024-05165-z
Abstrakt: Obesity, diabetes, and their cardiovascular and hepatic comorbidities are alarming public health issues of the twenty-first century, which share mitochondrial dysfunction, oxidative stress, and chronic inflammation as common pathophysiological mechanisms. An increasing body of evidence links the combined exposure to multiple environmental toxicants with the occurrence and severity of metabolic diseases. Endocrine disruptors (EDs) are ubiquitous chemicals or mixtures with persistent deleterious effects on the living organisms beyond the endocrine system impairment; in particular, those known as metabolism-disrupting chemicals (MDCs), increase the risk of the metabolic pathologies in adult organism or its progeny. Being largely lipophilic, MDCs mainly target the adipose tissue and elicit mitochondrial dysfunction by interfering with mitochondrial bioenergetics, biogenesis, dynamics and/or other functions. Plastics, when broken down into micro- and nano-plastics (MNPs), have been detected in several human tissues, including the liver. The harmful interplay between inflammatory and redox processes, which mutually interact in a positive feed-back loop, hence the term oxidative inflammation ("OxInflammation"), occurs both at systemic and organ level. In both liver and adipose tissue, oxinflammation contributes to the progression of the metabolic dysfunction-associated steatotic liver disease (MASLD). Moreover, it has been reported that individuals with MASLD may be more susceptible to the harmful effects of toxicants (mainly, those related to mitochondria) and that chronic exposure to EDs/MDCs or MNPs may play a role in the development of the disease. While liver has been systematically investigated as major target organ for ambient chemicals, surprisingly, less information is available in the literature with respect to the adipose tissue. In this narrative review, we delve into the current literature on the most studied environmental toxicants (bisphenols, polychlorinated biphenyls, phthalates, tolylfluanid and tributyltin, per-fluoroalkyl and polyfluoroalkyl substances, heavy metals and MNPs), summarize their deleterious effects on adipose tissue, and address the role of dysregulated mitochondria and oxinflammation, particularly in the setting of MASLD.
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests. Informed consent: Not applicable. Institutional review board statement: Not applicable.
(© 2024. The Author(s).)
Databáze: MEDLINE
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