Interactions of spontaneous abortion with FTO gene and dietary carotenoids; a case-control study.

Autor:	Amjadi A; Department of Nutrition, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran., Abbasi Mobarakeh K; Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran., Doaei S; Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran., Dorosti M; Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran., Nami S; Department of Clinical Biochemistry, Iran University of Medical Sciences, Tehran, Iran., Mirshafaei SR; Department of Applied Mathematics, Roudsar and Amlash branch, Islamic Azad University, Roudsar, Iran., Mirshafaei MA; Islamic Azad University, Tonekabon Mazandaran Branch, Tonekabon, Iran., Ataei Kachooei M; Faculty of Medicine, Shahrekord, University of Medical Sciences, Shahrekord, Iran., Shamsi-Goushki A; Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Saeedirad Z; Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Azizi Tabesh G; Department of Medical Genetics, School of Medicine, Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Khoshdooz S; Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Abdollahi M; Social Determinants of Health Research Center, and National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shekari S; Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran., Gholamalizadeh M; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Journal of nutritional science [J Nutr Sci] 2024 Nov 27; Vol. 13, pp. e75. Date of Electronic Publication: 2024 Nov 27 (Print Publication: 2024).
DOI:	10.1017/jns.2024.55
Abstrakt:	Spontaneous abortion (SA) is considered one of the most prevalent adverse outcomes of pregnancy. SA may occur due to genetic susceptibility and various maternal factors such as nutritional status. The aim of this study was to assess how dietary carotenoids and the FTO gene are related to SA. This case-control study included 192 women with a history of SA as the case group and 347 healthy women without history of SA as the control group. To evaluate carotenoid intake, a valid 168-item food frequency questionnaire (FFQ) was used. The FTO gene was genotyped for the presence of the rs9939609 polymorphism using the tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR). The results indicated a significant negative association between dietary intake of β-cryptoxanthin and SA in carriers of the TT genotype of the FTO rs9939609 polymorphism after adjustment for age, BMI, physical activity, smoking, alcohol drinking, and calorie intake (β = -0.28, P = 0.02). No association was found between SA with dietary intake of beta-carotene, alpha-carotene, lutein, and lycopene among carriers of different FTO genotypes. The FTO genotype may have an effect on the association between SA and carotenoid intake. Dietary intake of β-cryptoxanthin may act as a protective factor against SA only in carriers of the TT genotype of the FTO rs9939609 polymorphism. Competing Interests: The authors affirm that they do not possess any conflicting interests. (© The Author(s) 2024.)
Databáze:	MEDLINE
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