An In-Depth Insight into Clinical, Cellular and Molecular Factors in COVID19-Associated Cardiovascular Ailments for Identifying Novel Disease Biomarkers, Drug Targets and Clinical Management Strategies.

Autor:	AlTaweel M; Ministry of National Guard Health Affairs (Saudi Arabia), Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia., Almusaad A; King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia., Alkhazmari G; College of Medicine, Imam Abdulrahman Bin Faisal University, Saudi Arabia.; Department of Medicine, Imam Abdulrahman Al Faisal Hospital, Saudi Arabia., Alrowaily H; College of Medicine, Northern Border University, Saudi Arabia., Alsubaiee M; King Abdulaziz Hospital, Ministry of National Guard Health Affairs, Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia.; College of Nursing, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia., Husain MA; Department of Family Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia., Alomayrin N; College of Medicine, King Faisal University, Saudi Arabia., Almuaiweed R; College of Medicine, King Faisal University, Saudi Arabia., Aleid N; King Abdulaziz Hospital, Ministry of National Guard Health Affairs, Saudi Arabia., Alarfaj AA; Department of Family Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.; Department of Family Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia., Albahrani Z; King Abdulaziz Hospital, Ministry of National Guard Health Affairs, Saudi Arabia., Taleb Y; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia.; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Ahsa, Saudi Arabia., Jalbani AA; King Abdulaziz Hospital, Ministry of National Guard Health Affairs, Saudi Arabia., Almukhaylid S; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Ahsa, Saudi Arabia.; Clinical Laboratory Department, Johns Hopkins Aramco HealthCare, Saudi Arabia., Soliman A; Ministry of National Guard Health Affairs (Saudi Arabia), Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia.; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Ahsa, Saudi Arabia., Iqbal Z; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Ahsa, Saudi Arabia.; King Abdullah International Medical Research Centre (KAIMRC)/SSBMT, King Abdulaziz Medical City, Saudi Arabia.; Saudi Society for Blood and Bone Marrow Transplantation (SSBMT), Saudi Arabia.; Centre for Advanced Molecular Biology, University of the Punjab, Pakistan.; Department of Biology, Qarshi University, Pakistan.
Jazyk:	angličtina
Zdroj:	Archives of microbiology & immunology [Arch Microbiol Immunol] 2024; Vol. 8 (3), pp. 290-308. Date of Electronic Publication: 2024 Jul 19.
DOI:	10.26502/ami.936500177
Abstrakt:	COVID-19 was initially identified as a respiratory system disorder, but it has been reported to interact with and influence the cardiovascular system, in addition to many other body systems. Although COVID-19-associated cardiovascular (CV) complications are common, resulting in high acute phase mortality and a large number of morbidities in the chronic phase, thus severely impacting patients' quality of life and health outcomes, yet clinical, cellular, and molecular biological factors underlying the pathophysiology of cardiovascular complications associated with COVID-19 are poorly understood. This review investigates putative underlying clinical factors as well as cellular and molecular biological mechanisms by which COVID-19 leads to acute CV complications, including state-of-the-art genomic sequencing-based findings, and assessing the long-term CV consequences of COVID-19, aiming to shed light on developing strategies for differential diagnosis, risk prognostic stratification, prevention, and clinical management of CV sequels in COVID-19 patients. We found that the relationship between COVID-19 and CV risk is complex and multifaceted. Intriguingly, in addition to acute COVID-19 detertriuos effects, COVID-19 survivors may experience long-term CV effects as well that may have long-lasting clinical consequences. Here in this article, we provide a detailed account of a large number of genomic alterations, microRNAs, and novel viral as well as host proteins in CVDs associated with COVID-19, which has helped identify some novel drug targets to treat COVID-19-related cardiovascular complications. Competing Interests: Competing Interest The authors have declared that no competing interests exist. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Databáze:	MEDLINE
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