Resolution of Erythema Annulare Centrifugum With Lung Cancer Drug Therapy: A Case Report.

Autor:	Kagabu M; Post Graduate Clinical Education Center, Japanese Red Cross Akita Hospital, Akita, JPN., Odaka H; Department of Respiratory Medicine, Japanese Red Cross Akita Hospital, Akita, JPN., Takita Y; Department of Respiratory Medicine, Japanese Red Cross Akita Hospital, Akita, JPN., Tokairin T; Department of Pathology, Japanese Red Cross Akita Hospital, Akita, JPN., Nagai T; Department of Dermatology, Japanese Red Cross Akita Hospital, Akita, JPN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Nov 19; Vol. 16 (11), pp. e73977. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).
DOI:	10.7759/cureus.73977
Abstrakt:	Tumor-associated erythema annulare centrifugum is commonly observed in leukemia and lymphoma. In this case, we reported erythema annulare centrifugum associated with lung cancer that resolved following targeted drug therapy. A 71-year-old man with psoriasis visited our hospital with erythema annulare and pruritus. Initially, he was prescribed cyclosporine at a dose of 2.5 mg/kg suspecting a worsening of his psoriasis; however, this treatment was ineffective. Signs of paraneoplastic skin syndrome were observed, leading to a diagnosis of epidermal growth factor receptor mutation-positive lung adenocarcinoma (cT3N2M1c, stage IV, exon 19 del). After initiating osimertinib at a dose of 80 mg, the skin rash improved, and the tumor size was reduced. The final diagnosis was paraneoplastic erythema annulare centrifugum associated with lung cancer. This case highlights the potential resolution of erythema annulare centrifugum through lung cancer therapy, emphasizing the importance of considering lung cancer differential diagnosis when this skin condition is present. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Kagabu et al.)
Databáze:	MEDLINE
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