Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.

Autor: Posada-Quintero HF; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. hugo.posada-quintero@uconn.edu., Derrick BJ; Department of Emergency Medicine, Duke University, Durham, NC, USA.; Department of Anesthesiology, Duke University, Durham, NC, USA., Ellis MC; Department of Emergency Medicine, Duke University, Durham, NC, USA.; Department of Anesthesiology, Duke University, Durham, NC, USA., Natoli MJ; Department of Anesthesiology, Duke University, Durham, NC, USA., Winstead-Derlega C; Department of Emergency Medicine, Duke University, Durham, NC, USA.; Department of Anesthesiology, Duke University, Durham, NC, USA., Gonzalez SI; Department of Emergency Medicine, Duke University, Durham, NC, USA., Allen CM; Department of Emergency Medicine, Duke University, Durham, NC, USA.; Department of Anesthesiology, Duke University, Durham, NC, USA., Makowski MS; Department of Anesthesiology, Duke University, Durham, NC, USA.; Department of Medicine, Duke University, Durham, NC, USA., Keuski BM; Department of the Navy, Panama City, FL, USA., Moon RE; Department of Anesthesiology, Duke University, Durham, NC, USA.; Department of Medicine, Duke University, Durham, NC, USA., Freiberger JJ; Department of Anesthesiology, Duke University, Durham, NC, USA., Chon KH; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Jazyk: angličtina
Zdroj: Communications medicine [Commun Med (Lond)] 2024 Dec 19; Vol. 4 (1), pp. 270. Date of Electronic Publication: 2024 Dec 19.
DOI: 10.1038/s43856-024-00688-4
Abstrakt: Background: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO 2 ) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) which could impair performance or result in a seizure and subsequent drowning. We aimed to study the dynamics of the electrodermal activity (EDA) and heart rate (HR) while breathing elevated PO 2 in the hyperbaric environment (HBO 2 ) as a possible means to predict impending CNS-OT.
Methods: EDA is recorded during 50 subject exposures (26 subjects) to evaluate CNS-OT in immersed (head out of water) exercising divers in a hyperbaric chamber breathing 100% O 2 at 35 feet of seawater (FSW), (PO 2  = 2.06 ATA) for up to 120 min.
Results: 32 subject exposures exhibit symptoms "definitely" or "probably" due to CNS-OT before the end of the exposure, whereas 18 do not. We obtain traditional and time-varying spectral indices (TVSymp) of EDA to determine its utility as predictive physio markers. Variations in EDA and heart rate (HR) for the last 5 min of the experiment are compared to baseline values prior to breathing O 2 . In the subset of experiments where "definite" CNS-OT symptoms developed, we find a significant elevation in the mean ± standard deviation TVSymp value 57 ± 79 s and median of 10 s, prior to symptoms.
Conclusions: In this retrospective analysis, TVSymp may have predictive value for CNS-OT with high sensitivity (1.0) but lower specificity (0.48). Additional work is being undertaken to improve the detection algorithm.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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