Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals.

Autor: Lu C; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Nanping First Hospital Affiliated to Fujian Medical University, Nanping, 353000, China., Song C; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China., Yu Y; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China., Yang L; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China., Zheng W; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China., Luo F; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China., Xiao Y; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China., Luo J; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China. 18634835@qq.com.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China. 18634835@qq.com.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China. 18634835@qq.com., Xu J; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China. jiexu1520@163.com.; Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China. jiexu1520@163.com.; Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350000, China. jiexu1520@163.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Dec 19; Vol. 14 (1), pp. 30558. Date of Electronic Publication: 2024 Dec 19.
DOI: 10.1038/s41598-024-78842-0
Abstrakt: Mechanical properties and integrity of biodegradable Zn alloys during degradation holds significant importance. In this study, a Zn-Mg-Mn alloy with tensile strength of 414 MPa and an elongation of 26% was developed. The strength contributions of as-extruded Zn alloy from grain boundary strengthening, precipitation strengthening, and second phase strengthening. Degradation of the Zn alloy in Hank's solution exhibited a decreasing trend with prolonged immersion, eventually stabilizing at 16 μm/year. Corrosion morphology analysis revealed that the corrosion modes transformed from pitting corrosion to severely localized corrosion with prolonged immersion time, eventually lead to formation of large holes. Although the tensile strength of the Zn alloys remained relatively unchanged following varied immersion time, a substantial decrease in elongation was observed. The decreased elongation primarily attributed to the formation of surface corrosion pits or holes, exacerbating crack propagation during tension. Biocompatibility assessments of Zn alloys demonstrated that a 50% concentration of Zn alloy leach solution cultured with C3H10 and RMSC cells yielded cellular activity exceeding 80%, indicating excellent cytocompatibility. Alkaline phosphatase (ALP) and alizarin red staining results further underscored the remarkable early and late osteogenic properties exhibited by Zn-Mg-Mn alloy.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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