A Review on Circular RNA Translation and Its Implications in Disease.

Autor:	Wei HY; Bio-med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai, China. weiyh@sinh.ac.cn.; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China. weiyh@sinh.ac.cn., Fan XJ; Bio-med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai, China.; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Mao MW; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China.; Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2883, pp. 109-137.
DOI:	10.1007/978-1-0716-4290-0_5
Abstrakt:	The mRNA vaccine has emerged as a powerful tool against viral infection during the coronavirus disease 2019 (COVID-19) pandemic. In the post-COVID-19 era, the applications of mRNA-based therapy continue to expand and evolve. Circular RNA (circRNA), long assumed to be a noncoding RNA, has been proven to be translatable and subsequently developed as a next-generation mRNA modality due to its higher stability and wider therapeutic window. Nonetheless, the studies of circRNA translation and its application in diseases still present numerous technical features and challenges. In this chapter, we provide a summary and discussion on the mechanisms of circRNA translation and its applications in medicine development, aiming to serve as a reference and inspiration for readers interested in circRNA-based therapy. (© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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