IPD-Brain: An Indian histopathology dataset for glioma subtype classification.

Autor: Chauhan E; Centre for Visual Information Technology, International Institute of Information Technology, Hyderabad, 500032, India. ekansh.chauhan@research.iiit.ac.in., Sharma A; Centre for Visual Information Technology, International Institute of Information Technology, Hyderabad, 500032, India., Uppin MS; Department of Pathology, Nizam's Institute Of Medical Sciences, Hyderabad, 500082, India., Kondamadugu M; IHub-Data, International Institute of Information Technology, Hyderabad, 500032, India., Jawahar CV; Centre for Visual Information Technology, International Institute of Information Technology, Hyderabad, 500032, India., Vinod PK; Center for Computational Natural Sciences and Bioinformatics, International Institute of Information Technology, Hyderabad, 500032, India. vinod.pk@iiit.ac.in.
Jazyk: angličtina
Zdroj: Scientific data [Sci Data] 2024 Dec 19; Vol. 11 (1), pp. 1403. Date of Electronic Publication: 2024 Dec 19.
DOI: 10.1038/s41597-024-04225-9
Abstrakt: The effective management of brain tumors relies on precise typing, subtyping, and grading. We present the IPD-Brain Dataset, a crucial resource for the neuropathological community, comprising 547 high-resolution H&E stained slides from 367 patients for the study of glioma subtypes and immunohistochemical biomarkers. Scanned at 40x magnification, this dataset is one of the largest in Asia, specifically focusing on the Indian demographics. It encompasses detailed clinical annotations, including patient age, sex, radiological findings, diagnosis, CNS WHO grade, and IHC biomarker status (IDH1R132H, ATRX and TP53 along with proliferation index, Ki67), providing a rich foundation for research. The dataset is open for public access and is designed for various applications, from machine learning model training to the exploration of regional and ethnic disease variations. Preliminary validations utilizing Multiple Instance Learning for tasks such as glioma subtype classification and IHC biomarker identification underscore its potential to significantly contribute to global collaboration in brain tumor research, enhancing diagnostic precision and understanding of glioma variability across different populations.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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